2002
DOI: 10.1073/pnas.112183899
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Genomewide identification of proteins secreted by the Hrp type III protein secretion system of Pseudomonas syringae pv. tomato DC3000

Abstract: The ability of Pseudomonas syringae pv. tomato DC3000 to be pathogenic on plants depends on the Hrp (hypersensitive response and pathogenicity) type III protein secretion system and the effector proteins it translocates into plant cells. Through iterative application of experimental and computational techniques, the DC3000 effector inventory has been substantially enlarged. Five homologs of known avirulence (Avr) proteins and five effector candidates, encoded by genes with putative Hrp promoters and signatures… Show more

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Cited by 265 publications
(254 citation statements)
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“…Recent articles report a bias in the amino acid composition of TTSS signal sequences from P. syringae spp. and R. solanacearum as compared with N termini of nonsecreted proteins (12,14,19). We found that Xcv TTSS signal sequences share attributes with both R. solanacearum and Pst, but Xcv elements defining these signals are more similar to R. solanacearum.…”
Section: Discussionmentioning
confidence: 67%
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“…Recent articles report a bias in the amino acid composition of TTSS signal sequences from P. syringae spp. and R. solanacearum as compared with N termini of nonsecreted proteins (12,14,19). We found that Xcv TTSS signal sequences share attributes with both R. solanacearum and Pst, but Xcv elements defining these signals are more similar to R. solanacearum.…”
Section: Discussionmentioning
confidence: 67%
“…We found that the levels of Ser (14.8%), Pro (11.7%), and Leu (6.9%) in the first 55 aa of 20 Xcv TTSS effectors are statistically different from levels of Ser (8.3%), Pro (5.4%), and Leu (9.9%) in the C-terminal portions of these proteins. Other rules defined for Pst signal sequences are less conserved in Xcv and R. solanacearum (12,14). Hydrophobic residues at position 5 are rare in Pst, whereas 9 of 20 of the Xcv effectors have a Met, Ile, Leu, Val, Phe, Tyr, or Trp at this Contribution of Xops to Xcv Pathogenicity.…”
Section: Identity Of Xop Effectorsmentioning
confidence: 99%
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“…Bacterial Avr proteins are translocated into the host cells through a type III protein secretion system (Galan and Collmer, 1999) which, in the case of Pseudomonas syringae DC3000, is thought to deliver more than 30 effector proteins (Boch et al, 2002;Collmer et al, 2002;Fouts et al, 2002;Guttman et al, 2002;Petnicki-Ocwieja et al, 2002;Zwiesler-Vollick et al, 2002). AvrRPM1 and AvrRpt2 from P. syringae provide examples of such type III effector proteins that are recognized by the products of the RPM1 and RPS2 resistance genes, respectively (Dangl et al, 1992;Innes et al, 1993).…”
mentioning
confidence: 99%