Genomic analyses identify significant molecules and signaling pathways in ameloblastoma

Abstract

Ameloblastoma is a locally aggressive odontogenic neoplasm that occurs in the vicinity of the mandibular molars or ramus. However, the mechanisms of ameloblastoma are still unclear. Here, our objective is to identify the key genes and signaling pathways by analyzing the RNA-seq data. The GSE186489 was created by the Illumina HiSeq 2500 (Homo sapiens). The gene enrichments indicated that the Chemical carcinogenesis − reactive oxygen species and prion disease are the key related signaling pathways in the development of ameloblastoma. Moreover, we determined several interactive genes including KIF11, BUB1, CDCA8, CDC20, ASPM, TOP2A, CCNB1, AURKA, TTK, and NCAPG. Our study may shed insights on the mechanism of ameloblastoma.