2010
DOI: 10.1099/vir.0.026138-0
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Genomic analysis of the first laboratory-mouse papillomavirus

Abstract: A papillomavirus (PV) that naturally infects laboratory mice will provide an extremely valuable tool for PV research. We describe here the isolation, cloning and molecular analysis of the first novel laboratory-mouse PV, designated MusPV. This agent, recently identified in the tissues from florid and asymmetrical papillomas on the face of nude mice (NMRI-Foxn1

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Cited by 67 publications
(66 citation statements)
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“…The species-specificity of HPVs has hindered the development of mouse models, other than transgenic mice, that can reveal clues about HPV carcinogenesis (Campo, 2002;Borzacchiello et al, 2009;Gissmann and Nieto, 2009;Eckert et al, 2000;Stelzer et al, 2010;Kanodia et al, 2010). Other than MusPV Joh et al, 2011), the only PV associated with any mouse species is MmiPV1, isolated from a zoo colony of European harvest mice (Bernard et al, 2010;Sundberg et al, 1996). Although there are at least five additional rodent PVs (MnPV1, McPV2, RnPV1, MaPV1, and EdPV1;Joh et al, 2011;Bernard et al, 2010), none has been entirely satisfactory as a model system since they were isolated from wild or exotic rodent species.…”
Section: Introductionmentioning
confidence: 95%
See 1 more Smart Citation
“…The species-specificity of HPVs has hindered the development of mouse models, other than transgenic mice, that can reveal clues about HPV carcinogenesis (Campo, 2002;Borzacchiello et al, 2009;Gissmann and Nieto, 2009;Eckert et al, 2000;Stelzer et al, 2010;Kanodia et al, 2010). Other than MusPV Joh et al, 2011), the only PV associated with any mouse species is MmiPV1, isolated from a zoo colony of European harvest mice (Bernard et al, 2010;Sundberg et al, 1996). Although there are at least five additional rodent PVs (MnPV1, McPV2, RnPV1, MaPV1, and EdPV1;Joh et al, 2011;Bernard et al, 2010), none has been entirely satisfactory as a model system since they were isolated from wild or exotic rodent species.…”
Section: Introductionmentioning
confidence: 95%
“…Other than MusPV Joh et al, 2011), the only PV associated with any mouse species is MmiPV1, isolated from a zoo colony of European harvest mice (Bernard et al, 2010;Sundberg et al, 1996). Although there are at least five additional rodent PVs (MnPV1, McPV2, RnPV1, MaPV1, and EdPV1;Joh et al, 2011;Bernard et al, 2010), none has been entirely satisfactory as a model system since they were isolated from wild or exotic rodent species. MusPV appears to be a satisfactory early stage laboratory mouse model that will reveal insight into cancers caused by PVs .…”
Section: Introductionmentioning
confidence: 96%
“…The majority of PVs only infect epithelium and are highly host specific. The bovine papillomaviruses (BVPs) of the Deltapapillomavirus genus, however, have the ability to infect both epithe lial and mesenchymal cells of different species (Bernard et al, 2010;Joh et al, 2011;Munday et al, 2014). Lesions caused by PVs in domestic cats may be oral papillomas (Felis catus (Fca) PV1) , feline cu taneous viral plaques, Bowenoid carcinomas (FcaPV2 and FcaPV3) (Lange et al, 2009;Munday et al, 2013) and feline sarcoids.…”
Section: Introductionmentioning
confidence: 99%
“…To determine whether a de novo-generated MusPV1 genome can induce papilloma formation, the genome was synthesized according to the published sequence (16) and was either circularized by intramolecular religation or encapsidated into L1/L2 capsids of the homologous virus MusPV1 or the heterologous virus HPV 16. The in vivo infectivities of these three preparations in immunodeficient, athymic NCr nude mice were evaluated by inoculating their muzzles, the location originally described for the spontaneous MusPV1-induced papillomas (13), and following the animals for 3 months.…”
Section: Generation Of a Synthetic Full-length Muspv1 Genome In Vitromentioning
confidence: 99%