Genomic environment and digital expression of bovine endogenous retroviruses

Garcia-Etxebarria, Koldo; Jugo, Begoña M.

doi:10.1016/j.gene.2014.06.048

Cited by 5 publications

(7 citation statements)

References 44 publications

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“…These TEs contribute to the genomic structure and evolution of cattle [ 259 ]. The insertion of TEs may result in neighboring gene modulation and chromosomal duplications [ 237 ]. However, the expression of BoERVs varies according to developmental stage, organ, and tissue type [ 237 ].…”

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

“…The insertion of TEs may result in neighboring gene modulation and chromosomal duplications [ 237 ]. However, the expression of BoERVs varies according to developmental stage, organ, and tissue type [ 237 ]. For example, BoERVs located on chromosomes 2 and 4 are highly expressed in endocrine glands [ 237 ].…”

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

“…However, the expression of BoERVs varies according to developmental stage, organ, and tissue type [ 237 ]. For example, BoERVs located on chromosomes 2 and 4 are highly expressed in endocrine glands [ 237 ]. Gene ontology analysis revealed that the LTRs of BoERV16, BoERV3, and BoERV9 contain a binding motif for the TF retinoid-X receptor alpha (Rxra), which upregulates BoERV expression in the thyroid [ 237 ].…”

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

“…For example, BoERVs located on chromosomes 2 and 4 are highly expressed in endocrine glands [ 237 ]. Gene ontology analysis revealed that the LTRs of BoERV16, BoERV3, and BoERV9 contain a binding motif for the TF retinoid-X receptor alpha (Rxra), which upregulates BoERV expression in the thyroid [ 237 ]. In contrast, the ruminant-specific TEs MER41_BT and Bov-A2 are mainly expressed in bovine eight-cell embryos during development [ 240 ].…”

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

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Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review

Hossain,

Nyame,

Monde

2024

Biomolecules

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Endogenous retroviruses (ERVs) became a part of the eukaryotic genome through endogenization millions of years ago. Moreover, they have lost their innate capability of virulence or replication. Nevertheless, in eukaryotic cells, they actively engage in various activities that may be advantageous or disadvantageous to the cells. The mechanisms by which transcription is triggered and implicated in cellular processes are complex. Owing to the diversity in the expression of transcription factors (TFs) in cells and the TF-binding motifs of viruses, the comprehensibility of ERV initiation and its impact on cellular functions are unclear. Currently, several factors are known to be related to their initiation. TFs that bind to the viral long-terminal repeat (LTR) are critical initiators. This review discusses the TFs shown to actively associate with ERV stimulation across species such as humans, mice, pigs, monkeys, zebrafish, Drosophila, and yeast. A comprehensive summary of the expression of previously reported TFs may aid in identifying similarities between animal species and endogenous viruses. Moreover, an in-depth understanding of ERV expression will assist in elucidating their physiological roles in eukaryotic cell development and in clarifying their relationship with endogenous retrovirus-associated diseases.

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Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

Section: Tfs Associated With Erv Ltr Activation In Other Speciesmentioning

confidence: 99%

See 2 more Smart Citations

Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review

Hossain,

Nyame,

Monde

2024

Biomolecules

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“…Remarkably, retrovirus-derived sequences account for 8.8% of the human genome [22], 10% of the mouse genome [23], and 18% of the bovine genome [24]. A study on the location and expression of bovine ERVs, as well as the characteristics of neighboring genes, has revealed that up to 1610 bovine genes contain bovine ERVs (BERVs) inserted within their introns [25]. Most of these BERVs are oriented in the antisense direction, and several genes located in proximity to BERVs appear to be associated with viral response and chromatin assembly [25].…”

Section: The Principle Of Genomic Rewiring During Waves Of Retroviral...mentioning

confidence: 99%

Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle

Sakurai,

Kusama,

Imakawa

2023

Biomolecules

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Viviparity is made possible by the placenta, a structure acquired relatively recently in the evolutionary history of eutherian mammals. Compared to oviparity, it increases the survival rate of the fetus, owing to the eutherian placenta. Questions such as “How was the placenta acquired?” and “Why is there diversity in placental morphology among mammalian species?” remain largely unsolved. Our present understanding of the molecules regulating placental development remains unclear, owing in no small part to the persistent obscurity surrounding the molecular mechanisms underlying placental acquisition. Numerous genes associated with the development of eutherian placental morphology likely evolved to function at the fetal–maternal interface in conjunction with those participating in embryogenesis. Therefore, identifying these genes, how they were acquired, and how they came to be expressed specifically at the fetal–maternal interface will shed light on some crucial molecular mechanisms underlying placental evolution. Exhaustive studies support the hypothesis that endogenous retroviruses (ERVs) could be evolutional driving forces for trophoblast cell fusion and placental structure in mammalian placentas including those of the bovine species. This review focuses on bovine ERVs (BERVs) and their expression and function in the placenta.

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Comparative analysis of active retrotransposons in the transcriptomes of three species of heteromyid rodents

Marra

DeWoody

2015

Gene

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Genomic environment and digital expression of bovine endogenous retroviruses

Cited by 5 publications

References 44 publications

Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review

Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review

Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle

Comparative analysis of active retrotransposons in the transcriptomes of three species of heteromyid rodents

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