Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases

Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects

“…Inflammation is a crucial initiator that regulates IVDD pathophysiology, weakens anabolism, and enhances catabolism in NP cells [ 15 ]. The pathogenesis of inflammation in IVDD includes recruitment of inflammatory cells, secretion of inflammatory mediators and activation of inflammatory signaling pathways, which contribute to the NP cells degeneration [ 16 , 17 ]. Moreover, inflammation is associated with attenuated autophagy and enhanced fibrosis in process of degeneration [ 18 , 19 ].…”