Genomic profiling as predictor of toxicity in patients with advanced colorectal cancer treated with platinum-based chemotherapy

Park, D. J.; Yun, Jie; Yang, Dongyun; Iqbal, Syma; Press, O.; Groshen, Susan; Gordon, Michael A.; Zhang, W.; Lenz, Heinz‐Josef

doi:10.1200/jco.2004.22.90140.3627

Cited by 2 publications

(2 citation statements)

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“…Among polymorphic germinal variants of ERCC1 , synonymous variants in 118 th codon (Asn118Asn) are mostly studied in the context of response to oxaliplatin therapy. This synonymic substitution is associated with the altered gene expression at mRNA and protein levels, and, as a consequence, altered NER efficacy and response to oxaliplatin [ 112 - 114 ]. The frequency of ERCC1 allele, which is associated with reduced gene expression and better response to chemotherapy, is about 35% in the European population [ 114 ].…”

Section: Excision Repair Systemmentioning

confidence: 99%

“…This synonymic substitution is associated with the altered gene expression at mRNA and protein levels, and, as a consequence, altered NER efficacy and response to oxaliplatin [ 112 - 114 ]. The frequency of ERCC1 allele, which is associated with reduced gene expression and better response to chemotherapy, is about 35% in the European population [ 114 ]. The same observations have been marked for the non-synonymous variants in ERCC2 (Lys751Gln) [ 115 ] and XRCC1 (Arg399Gln) genes [ 116 ].…”

Section: Excision Repair Systemmentioning

confidence: 99%

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Important molecular genetic markers of colorectal cancer

et al. 2016

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Colorectal cancer (CRC) ranks third in the incidences of cancer morbidity and mortality worldwide. CRC is rather heterogeneous with regard to molecular genetic characteristics and pathogenic pathways. A wide spectrum of biomarkers is used for molecular subtype determination, prognosis, and estimation of sensitivity to different drugs in practice. These biomarkers can include germline and somatic mutations, chromosomal aberrations, genomic abnormalities, gene expression alterations at mRNA or protein level and changes in DNA methylation status. In the present review we discuss the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.

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Section: Excision Repair Systemmentioning

confidence: 99%