Genomic regions associated with ventro-cranial chronic pleuritis in pig

Sørensen, Kirsten Kørup; Gregersen, Vivi Raundahl; Christensen, Ole; Velander, Ingela; Berthou, Christian

doi:10.1111/j.1439-0388.2010.00914.x

Cited by 6 publications

(7 citation statements)

References 19 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As expected from several studies on the high susceptibility of pigs of the German Landrace breed to Actinobacillus pleuropneumoniae (Sørensen et al 2011;Reiner et al 2014a, b;Hoeltig et al 2009), in the present study 36 of the infected pigs died or had to be euthanized before day 7 of the infection trial. Thirty-seven of the infected pigs exhibited RHS values below 10 or higher than 90.…”

Section: Discussionsupporting

confidence: 84%

“…Up to now, information on genetic resistance to pleuropneumonia has only been available as quantitative trait loci (QTL) mapped on the basis of microsatellite markers (Hoeltig et al 2009;Gregersen et al 2010;Sørensen et al 2011;Reiner et al 2014a, b). Gregersen et al (2010) found six QTL on SSC 2,8,12,13,14 and 18 in a study with 7470 animals, significant at a chromosome-wide level, when screening for dorso-caudal chronic pleuritis in slaughter pigs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Candidate genes and gene markers for the resistance to porcine pleuropneumonia

et al. 2020

View full text Add to dashboard Cite

Actinobacillus (A.) pleuropneumoniae is one of the most important respiratory pathogens in global pig production. Antimicrobial treatment and vaccination provide only limited protection, but genetic disease resistance is a very promising alternative for sustainable prophylaxis. Previous studies have discovered multiple QTL that may explain up to 30% of phenotypic variance. Based on these findings, the aim of the present study was to use genomic sequencing to identify genetic markers for resistance to pleuropneumonia in a segregating commercial German Landrace line. 163 pigs were infected with A. pleuropneumoniae Serotype 7 through a standardized aerosol infection method. Phenotypes were accurately defined on a clinical, pathological and microbiological basis. The 58 pigs with the most extreme phenotypes were genotyped by sequencing (next-generation sequencing). SNPs were used in a genome-wide association study. The study identified genome-wide associated SNPs on three chromosomes, two of which were chromosomes of QTL which had been mapped in a recent experiment. Each variant explained up to 20% of the total phenotypic variance. Combined, the three variants explained 52.8% of the variance. The SNPs are located in genes involved in the pathomechanism of pleuropneumonia. This study confirms the genetic background for the host's resistance to pleuropneumonia and indicates a potential role of three candidates on SSC2, SSC12 and SSC15. Favorable gene variants are segregating in commercial populations. Further work is needed to verify the results in a controlled study and to identify the functional QTN.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Candidate genes and gene markers for the resistance to porcine pleuropneumonia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Concerning A. pleuropneumoniae, differences in susceptibility among pigs of different populations have been shown in a detailed and comprehensive clinical study by Hoeltig et al (2009). Gregersen et al (2010) and Sorensen et al (2011) mapped QTL for chronic pleuropneumonia and ventro-cranial chronic pleuritis, respectively, providing further evidence for genetic involvement in lung lesions with at least partial involvement of A. pleuropneumoniae.…”

Section: Introductionmentioning

confidence: 72%

Identification of QTL affecting resistance/susceptibility to acute Actinobacillus pleuropneumoniae infection in swine

et al. 2014

View full text Add to dashboard Cite

Actinobacillus pleuropneumoniae is among the most important pathogens worldwide in pig production. The agent can cause severe economic losses due to decreased performance, acute or chronic pleuropneumonia and an increased incidence of death. Therapeutics cannot be used in a sustainable manner, and vaccination is not always available, but discovering more about host defence and disease mechanisms might lead to new methods of prophylaxis. The aim of the present study was to detect quantitative trait loci (QTL) associated with resistance/susceptibility to A. pleuropneumoniae. Under controlled conditions, 170 F2 animals of a Hampshire/Landrace family, with known differences in founder populations regarding A. pleuropneumoniae resistance, were challenged with an A. pleuropneumoniae serotype 7 aerosol followed by a detailed clinical, radiographic, ultrasonographic, pathological and bacteriological examination. F2 pigs were genotyped with 159 microsatellite markers. Significant QTL were identified on Sus scrofa chromosomes (SSC) 2, 6, 12, 13, 16, 17 and 18. They explained 6-22% of phenotypic variance. One QTL on SSC2 reached significance on a genome-wide level for five associated phenotypic traits. A multiple regression analysis revealed a combinatory effect of markers SWR345 (SSC2) and S0143 (SSC12) on Respiratory Health Score, Clinical Score and the occurrence of death. The results indicate the genetic background of A. pleuropneumoniae resistance in swine and provide new insights into the genetic architecture of resistance/susceptibility to porcine pleuropneumonia. The results will be helpful in identifying the underlying genes and mechanisms.

show abstract

“…Several QTLs on SSC 2, 12 and 13 have been detected for EP‐related respiratory diseases (Sorensen et al . ; Okamura et al . ; Reiner et al .…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association studies identify susceptibility loci affecting respiratory disease in Chinese Erhualian pigs under natural conditions

Huang

Deng

et al. 2016

Anim Genet

View full text Add to dashboard Cite

Prevalence of swine respiratory disease causes poor growth performance in and serious economic losses to the swine industry. In this study, a categorical trait of enzootic pneumonia-like (EPL) score representing the infection gradient of a respiratory disease, more likely enzootic pneumonia, was recorded in a herd of 332 Chinese Erhualian pigs. According to their EPL scores and the disease effect on weight gains, these pigs were grouped into controls (EPL score ≤ 1) and cases (EPL score > 1). The weight gain of the case group reduced significantly at days 180, 210, 240 and 300 as compared to the control group. The heritability of EPL score was estimated to be 0.24 based on the pedigree information using a linear mixed model. All 332 Erhualian pigs and their nine sire parents were genotyped with Illumina Porcine 60K SNP chips. Two genome-wide association studies were performed under a generalized linear mixed model and a case-control model respectively. In total, five loci surpassed the suggestive significance level (P = 2.98 × 10 ) on chromosomes 2, 8, 12 and 14. CXCL6, CXCL8, KIT and CTBP2 were highlighted as candidate genes that might play important roles in determining resistance/susceptibility to swine EP-like respiratory disease. The findings advance understanding of the genetic basis of resistance/susceptibility to respiratory disease in pigs.

show abstract

Genomic regions associated with ventro-cranial chronic pleuritis in pig

Cited by 6 publications

References 19 publications

Candidate genes and gene markers for the resistance to porcine pleuropneumonia

Candidate genes and gene markers for the resistance to porcine pleuropneumonia

Identification of QTL affecting resistance/susceptibility to acute Actinobacillus pleuropneumoniae infection in swine

Genome-wide association studies identify susceptibility loci affecting respiratory disease in Chinese Erhualian pigs under natural conditions

Contact Info

Product

Resources

About