Genomic structure and chromosomal localization of processed pseudogenes for human RBP-Jk

Zhang, Mingdi; Tang, Xiaoou; Jin, Chen; Logeat, Frédérique; Israël, Alain; Kondo, Shinichi; Sun, Kun; Yokoyama, Kazushige

doi:10.1007/bf01892384

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Amakawa et al (1993) reported that the functional human gene for KBF2/RBP-Jk was assigned to chromosome 3q25 and two pseudogenes IGKJRBP 1 and IGKJR-BP 2 were mapped to 9pt3 and 9q13, respectively. We also reported the similar intense signals of KBF2/RBP-Jk pseudogenes on two sites of chromosome 9p13 and 9q13 (Zhang et al, 1994). Thus, more than four or at least four different genomic pseudogenes of humen KBF2/RBP-Jk may be present in human chromosome.…”

supporting

confidence: 68%

“…Thus, KBF2/ RBP-Jk seems likely to mediate the EBNA2-dependent transactivation of both cellular and viral genes (Zimble et al, 1994). Since the location of the functional gene for RBP-JI~ was reported at human chromosome 3q25 (Amakawa et alo, 1993), while the location was chromosome 9p13 or 9q 13 in the case of pseudogenes (Zhang et al, 1994), we were interested in determining the site(s) of other functional gene(s) for KBF2/RBP-Jk. We found, by FISH (fluorescence in situ hybridization), that the functional gene for KBF2/RBP-Jk was located at chromosome 9p12-13 and 9q13.…”

mentioning

confidence: 99%

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Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescencein situ hybridization

et al. 1997

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SummaryThe transcription factor KBF2 has been characterized as a factor that binds to the NFkB site of mouse major histocompatibility complex (MHC) class I genes and its amino acid sequence has been shown to be identical to those of members of the recombination signalsequence binding protein (RBP-Jk) family. Previous studies by Amakawa et al. (Genomics 17, 306-315, 1993) demonstrated that the functional gene is localized at human chromosome 3q25. However, in the present study we showed by in situ hybridization With the functional KBF2/ RBPJk cosmid clone that the gene is localized at 9p12-13 and 9q13, namely, at the same loci as pseudogenes that were reported previously (Zhang et al., Jpn J Human Genet 39, 391-401, 1994). Key Words KBF2, RBP-Jk, cosmid, in situ hybridizationThe major histocompatibility complex (MHC) class I antigens specified by MHC class I genes play a key role in a number of immunological processes, particularly in the recognition of foreign antigens by cytotoxic T cells and natural killer ceils of the host (Zinkernagel and Doherty, 1979). In the mouse, the promoters of the K b and L d class I MHC genes have been used as models in studies of transcription (Israel et al., 1989). A factor designated KBF2, which can bind as a monomer to conserved sequence element (TGGGGATTCCCCA) located 165 bp upstream of the initiation site of the H-2K b class I gene. Interestingly, the same

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supporting

confidence: 68%

mentioning

confidence: 99%

Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescencein situ hybridization

et al. 1997

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“…Recently, Tang et al (1997) corrected this localization and reported that two copies of the functional gene map to chromosome 9p13 → p12 and 9q13, respectively, the same loci which have been described as containing two Rbpsuh pseudogenes (Amakawa et al, 1993 andZhang et al, 1994).…”

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confidence: 99%

Assignment of the mouse <i>Rbpsuh</i> gene to chromosome 5 and one processed pseudogene <i>Rbpsuh-rs3</i> to chromosome 6

Himmelbauer

Zechner³

et al. 2000

Cytogenet Genome Res

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Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism

Echeverri

Oates

2007

Developmental Biology

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Vertebrate embryos faithfully produce bilaterally symmetric somites that give rise to repetitive body structures such as vertebrae and skeletal muscle. Body segmentation is regulated by a cyclic gene expression system, containing the Delta-Notch pathway and targets, which generates bilaterally symmetric oscillations across the Pre-Somitic Mesoderm (PSM). The position of the forming somite boundary is controlled by interaction of this oscillator with a determination front comprised of opposing gradients of FGF and retinoic acid (RA) signalling. Disruption of RA production leads to asymmetries in cyclic gene expression, but the link between RA and the oscillator is unknown. In somitogenesis, Notch signalling activates target genes through the transcription factor Suppressor of Hairless (Su(H)). Here, we report that two Su(H) genes coordinate bilaterally symmetric positioning of somite boundaries in the zebrafish embryo. Combined Su(H) gene knockdown caused defects in visceral left/right asymmetry, neurogenic lateral inhibition, and symmetrical failure of the segmentation oscillator. However, by selectively down-regulating Su(H)2 or Su(H)1 function using specific antisense morpholinos, we observed asymmetric defects in anterior or posterior somite boundaries, respectively. These morphological abnormalities were reflected by underlying asymmetric cyclic gene expression waves in the presomitic mesoderm, indicating a key role for Su(H) in coordinating the left-right symmetry of this process. Strikingly, expression of the RA-degrading enzyme cyp26a1 in the tailbud was controlled by Su(H) activity, and morpholino knockdown of cyp26a1 alone caused asymmetric cyclic dlc expression, suggesting that excess RA in the tailbud may contribute to the cyclic asymmetries. Indeed, exogenous RA was sufficient to generate asymmetric expression of all cyclic genes. Our observations indicate that one element of the Notch signalling pathway, Su(H), is required for control of RA metabolism in the tailbud and that this regulation is involved in bilateral symmetry of cyclic gene expression and somitogenesis.

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Genomic structure and chromosomal localization of processed pseudogenes for human RBP-Jk

Cited by 3 publications

References 22 publications

Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescencein situ hybridization

Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescencein situ hybridization

Assignment of the mouse <i>Rbpsuh</i> gene to chromosome 5 and one processed pseudogene <i>Rbpsuh-rs3</i> to chromosome 6

Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism

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