Genomics, Other “Omic” Technologies, Personalized Medicine, and Additional Biotechnology-Related Techniques

Sindelar, Robert D.

doi:10.1007/978-1-4614-6486-0_8

Cited by 7 publications

(2 citation statements)

References 142 publications

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“…Genomic, transcriptomic, proteomic, and metabolomic technologies have transformed agriculture, medicine, food science, and life science. New insights from plant-microbe interaction omics illuminate the complex interactions between plants and microbes and their effects on crop productivity, sustainability, and environmental resilience (Sindelar, 2024 ). These advances have revealed a rich tapestry of plant-associated microbial species and their roles in nutrient cycling, disease control, stress tolerance, and plant-microbe signaling networks.…”

Section: Omics Advancement and Applicationsmentioning

confidence: 99%

Omics approaches in understanding the benefits of plant-microbe interactions

Jain,

Sarsaiya,

Singh

et al. 2024

Front. Microbiol.

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Plant-microbe interactions are pivotal for ecosystem dynamics and sustainable agriculture, and are influenced by various factors, such as host characteristics, environmental conditions, and human activities. Omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, have revolutionized our understanding of these interactions. Genomics elucidates key genes, transcriptomics reveals gene expression dynamics, proteomics identifies essential proteins, and metabolomics profiles small molecules, thereby offering a holistic perspective. This review synthesizes diverse microbial-plant interactions, showcasing the application of omics in understanding mechanisms, such as nitrogen fixation, systemic resistance induction, mycorrhizal association, and pathogen-host interactions. Despite the challenges of data integration and ethical considerations, omics approaches promise advancements in precision intervention and resilient agricultural practices. Future research should address data integration challenges, enhance omics technology resolution, explore epigenomics, and understand plant-microbe dynamics under diverse conditions. In conclusion, omics technologies hold immense promise for optimizing agricultural strategies and fortifying resilient plant-microbe alliances, paving the way for sustainable agriculture and environmental stewardship.

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Section: Omics Advancement and Applicationsmentioning

confidence: 99%

Omics approaches in understanding the benefits of plant-microbe interactions

Jain,

Sarsaiya,

Singh

et al. 2024

Front. Microbiol.

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“…Similarly, transcriptome analysis includes the entire mRNA set, again using NGS or biochip technology. Proteome analysis of a cell or tissue means studying the entire protein content of a biological specimen, usually using mass spectroscopy, which is also used in metabolomics, assessing the meta bolites profile in individual biological systems or tissues [5].…”

Section: Postgenome Era and Advanced Omics Technologiesmentioning

confidence: 99%

Personalized laboratory medicine: a patient-centered future approach

Žitnik

Černe

Mancini

et al. 2018

Clinical Chemistry and Laboratory Medicine (CCLM)

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In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

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Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

Pashang,

Gilbride,

Wenk

2024

ChemBioEng Reviews

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Prokaryotic cells are pivotal in meeting the global demand for biopharmaceuticals. However, challenges such as the absence of advanced technology for real‐time monitoring, standardized testing methodologies, and quality risk assessment of microbial activity have led to increased production costs, delays, and shortages of biopharmaceutical products. A thorough understanding of how biomolecule production interacts with microbial population structure and function is vital for improving continuous manufacturing and process automation. In this review, we discuss the current microbiological techniques that meet good manufacturing practice requirements in industrial settings, explore the advantages of monitoring and measuring biomass growth efficiency and turnover rates beyond regulatory criteria for product release, and provide a critical assessment of the current state of knowledge on bioassays and engineering tools for biomolecule yield measurement and monitoring. Furthermore, we identify areas for future development, potential applications, and the need for interdisciplinary innovation to drive future research, including advancing bioassays for biopharmaceutical wastewater risk.

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Genomics, Other “Omic” Technologies, Personalized Medicine, and Additional Biotechnology-Related Techniques

Cited by 7 publications

References 142 publications

Omics approaches in understanding the benefits of plant-microbe interactions

Omics approaches in understanding the benefits of plant-microbe interactions

Personalized laboratory medicine: a patient-centered future approach

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

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