Genotoxic effects in peripheral blood and urine of workers exposed to low level benzene.

Abstract

Blood samples were obtained from a population of refinery workers representing different age groups. Sixty six men with low average exposure to benzene and 33 male controls were investigated. An examination of cell cycle kinetics and sister chromatid exchange was carried out on control and exposed individuals. No significant differences were found between groups of individuals varying in their drinking and smoking habits or their exposure to diagnostic x rays. Individuals with the lowest and highest phenol values were examined for urine mutagenicity, with urinary phenol used here as an indicator of benzene exposure. There was no difference in the number of revertant colonies in strains TA98 and 100 between the high and low urinary phenol groups. There were also no differences in any of the biochemical measures or haematological parameters investigated in all the individuals except that higher values for mean corpuscular volume were found in exposed than in control individuals. These values, however, were within the normal clinical range.

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

“…Reduction in complete blood cell (CBC) count to levels below the normal limit is termed as pancytopenia, leading to aplastic anemia (16). Some authors have proposed hemoglobin (17,18), mean corpuscular volume (MCV) (19,20), absolute lymphocyte count (21)(22)(23), and CBC count (24)(25)(26) as appropriate tests for the detection of toxic effects.…”

Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas

“…As reported earlier, several enzymes contribute to a redox imbalance during benzene metabolism by sustaining a certain level of inflammation that continuously recruits innate and adaptive immune cells producing high levels of proinflammatory cytokines that perpetuate this vicious cycle. The production of ROS and free oxygen radicals during benzene metabolism was associated with the alteration of DNA, damage to DNA-associated protein and chromosomal breaks, and aberration [21,22]. In particular, HQ and BQ are powerful inductors of DNA strand breakage [23].…”

Radiopaque Hemocompatible Ruminant-Sourced Gut Material with Antimicrobial Physiognomies for Biomedical Applications in Diabetics

“… 26 Moreover aromatic benzene is reported to be genotoxic, causing DNA reactivity from free-radical-mediated oxidative damage, mutagenicity, and clastogenicity, instigating micronucleus, chromosomal aberrations from single- or double-strand breaks, aneuploidy, sister chromatid exchange, and aneugenesis. 27 − 29 …”

“…Introduction of hydrophobic nonbiodegradable polymers is known to cause anaphylactic reactions and neurological and cardiovascular symptoms. − Leaching of the contrast agents from a physically mixed heterogeneous composition such as BaSO 4 evokes undesirable biochemical responses such as the activation of osteoclasts . Moreover aromatic benzene is reported to be genotoxic, causing DNA reactivity from free-radical-mediated oxidative damage, mutagenicity, and clastogenicity, instigating micronucleus, chromosomal aberrations from single- or double-strand breaks, aneuploidy, sister chromatid exchange, and aneugenesis. − …”