Genotoxic Effects on buccal Cells of Workers Exposed to Fogging Sprays during Fogging Operation

Awang, Normah

doi:10.26717/bjstr.2017.01.000433

BJSTR

2017

DOI: 10.26717/bjstr.2017.01.000433

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Genotoxic Effects on buccal Cells of Workers Exposed to Fogging Sprays during Fogging Operation

Normah Awang¹

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2021

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The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

Imran

Yazid

Cui

et al. 2021

IJMS

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Telomere repeat binding factor 2 (TRF2) has a well-known function at the telomeres, which acts to protect the telomere end from being recognized as a DNA break or from unwanted recombination. This protection mechanism prevents DNA instability from mutation and subsequent severe diseases caused by the changes in DNA, such as cancer. Since TRF2 actively inhibits the DNA damage response factors from recognizing the telomere end as a DNA break, many more studies have also shown its interactions outside of the telomeres. However, very little has been discovered on the mechanisms involved in these interactions. This review aims to discuss the known function of TRF2 and its interaction with the DNA damage response (DDR) factors at both telomeric and non-telomeric regions. In this review, we will summarize recent progress and findings on the interactions between TRF2 and DDR factors at telomeres and outside of telomeres.

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The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

Imran

Yazid

Cui

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

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Genotoxic Effects on buccal Cells of Workers Exposed to Fogging Sprays during Fogging Operation

Cited by 1 publication

References 12 publications

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

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