Genotoxicity and Histopathological Studies on the Liver and Kidney of Male Rats Fed on Diet Containing Waste Fat Released From Chicken During Grilling Process

Hassan, Gamal M.; Mazher, Kh. M.

doi:10.21608/ejgc.2010.11064

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…In this study, Masson's trichrome stained sections of control group showed few collagen fibers in the renal interstitium around renal corpuscles and tubules. These results are close to those of Hassan & Mazher, (2011) [39] .…”

Section: Discussionsupporting

confidence: 93%

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Amin,

Agaga

2022

Journal of Medical Histology

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Introduction: Perfluorinated chemicals (PFCs) are materials that have many important industrial applications. Quercetin is a unique bioflavonoid that known with its antioxidant activity. Aim: To evaluate the histopathological effect of (PFOS) on rat renal cortex and the possible protective role of Quercetin. Materials and Methods: 45 adult male albino rats were divided into three groups, each contained 15 rats. The first group was the control group (I), which was splitted into three equal subgroups. The second group was (PFOS) receiving group (II) at a dose of 20mg /kg/day by gavage for 28 days. The third group was the protective group (III) which received the same dose of (PFOS) as group (II) in combination with Quercetin at a dose of 50 mg/kg b.w orally for 28 days. At the end of the study, the kidneys were dissected out and prepared for light microscopic examination. Results:The kidney sections of (PFOS) receiving group showed distortion of normal histology in the form of variations in the size and shape of renal glomeruli, peri glomerular inflammatory cell infiltrations, Disorganized renal tubules with dark stained (pyknotic) nuclei, cystic luminal dilatation and cytoplasmic vacuolations. In addition, some cortical convoluted tubules showed areas of interstitial hemorrhage, necrosis and exfoliation of tubular epithelial cells. Increased collagen fibers deposition and immune expression of PCNA and INOS stained sections. All these findings were improved by co-administration of Quercetin. Conclusion: Quercetin played an important role in improving the toxic effects of (PFOS) on kidney tissue of adult male rats.

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Section: Discussionsupporting

confidence: 93%

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Amin,

Agaga

2022

Journal of Medical Histology

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“…Masson's trichrome stained sections showed few collagen fibers in the interstitium of the renal cortex around the renal corpuscles and tubules. The results agreed with Hassan et al [15].…”

Section: Discussionsupporting

confidence: 93%

Structural Changes Induced By Gibberellic Acid in the Renal Cortex of Adult Male Albino Rats

Sabry¹

2017

MOJAP

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“…The resulting images were subsequently named "Comet" because of their appearance and their total length was considered directly related to the DNA damage. From that moment a range of applications of the Comet assay have been used in investigations of the physiochemical behavior of DNA, through studies of cellular responses of DNA damage, to bio-monitoring of human population (Hassan and Mazhar, 2010).…”

Section: Discussionmentioning

confidence: 99%

Investigating the use of Sphaeroma serratum (Crustacea, Isopoda) as bio-indicator for heavy metals pollution in Lake Timsah, Suez Canal using alkaline comet assay technique

El-Din

Yaegashi

Mohamed

et al. 2014

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Pollution of the environment with heavy metals is a serious problem that is recognized in most countries in the world. Lake Timsah as an important lake in Suez Canal is highly polluted and receiving different sources of contaminations. However, attention and alarm thresholds of these parameters only concern the toxic effects of the polluting substances studied and do not take into consideration the question of chronic exposure at low doses of noxious chemicals. The physico-chemical parameters only provide snapshots of the condition of a water body and don't provide the integrative measure of overall health of any water body. On the other hand, crustaceans are used as bio-indicators in various aquatic systems in bio-accumulation experiments and in field studies. The crustacean isopod, Sphaeroma serratum which is found in large numbers at Lake Timsah was used for further investigation for detecting its DNA damages cause by the pollution. The comet assay technique which derives its name from the comet-like shape that cells with damaged DNA acquire was applied in this study in order to investigate on what level such poor water conditions in Lake Timsah can deform the DNA of its biota. It is recommended than other tests as it requires only a very small number of cells and these cells do not need to be undergoing active division. The present study confirmed the applicability of the alkaline comet assay technique as a sensitive tool for environmental monitoring. Also, it can be suggested that aquatic S. serratum which is a very tolerant species can resist pollution and can be used as a reliable bio-indicator of DNA damage.

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Genotoxicity and Histopathological Studies on the Liver and Kidney of Male Rats Fed on Diet Containing Waste Fat Released From Chicken During Grilling Process

Cited by 6 publications

References 13 publications

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Structural Changes Induced By Gibberellic Acid in the Renal Cortex of Adult Male Albino Rats

Investigating the use of Sphaeroma serratum (Crustacea, Isopoda) as bio-indicator for heavy metals pollution in Lake Timsah, Suez Canal using alkaline comet assay technique

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