Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication

Ayed-Boussema, Imen; Rjiba, Karima; Moussa, Amal; Mnasri, Nourhène; Bacha, Hassen

doi:10.1007/s11356-011-0588-z

Cited by 19 publications

(9 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rattner and Hoffman (1984) report the inhibition of AChE after the administration of sublethal oral doses of the organophosphate (OF) insecticide acephate to wild mice (M. musculus, P. leucopus and M. pennsylvanicus); inhibition rates were similar to those reported in this study (16 to 40 %) at doses between 25 mg/kg and 100 mg/kg of food for 5 days. In addition, the inhibition rates recorded in our results are seemingly harmless for the mouse populations, as in other U/min/mg prot ever, the average values recorded in this work are higher than those reported in other (experimental) studies, where mean activity ranges from 0.2 to 2.5 U/min/mg protein (Ayed-Boussema et al 2012;Panemangalore and Baby 2000;Yilmaz et al 2004). In this regard, catalase is a biomarker that can react in different ways, i. e., inhibition or activation, depending on various factors, mainly the dose of the xenobiotic, time of exposure, or a combination of various compounds (van der Oost et al 2003).…”

Section: Resultscontrasting

confidence: 66%

Presence of organochlorine pesticides and characterization of biomarkers in wild mice living in crop fields

Herrera

Escalona‐Segura

González-Jaurégui

et al. 2018

Therya

View full text Add to dashboard Cite

The use of pesticides in crops bordering conservation areas poses risks for wildlife incidentally exposed; its effects in the Yucatan Peninsula, Mexico, are still unknown. Wild mice that inhabit farming land play a key ecological role, and can also be used as bioindicators of wildlife exposure to pollutants. The objectives of this work were to determine the presence of organochlorine pesticides (OC) in liver and evaluate the seasonal response of enzymatic biomarkers (BM) such as acetylcholinesterase (AChE), glutathione-S-transferase (GST), and catalase (CAT). Wild mice (Mus musculus) were captured between June 2015 and April 2016 in a watermelon crop of a rural community in Quintana Roo, Mexico. Individual mice were sacrificed in situ, followed by tissue dissection (liver, brain and skeletal muscle). Pesticides were determined by gas chromatography; BM activity was estimated by spectrophotometry. We captured 35 individuals, with a capture success of 2.33%. The prevailing OCs detected were drines in both climatic seasons. The rainy season influenced the activity of biomarkers to a greater extent, since AChE showed a lower activity (16 % and 40 % in brain and liver, respectively). GST was activated during the same season (77 % higher), while CAT did not show significant differences between seasons. There was no significant correlation between OC concentrations and biomarker activity, except for drines and AChE in the brain. OC concentrations recorded in the present work are below (2-and 20-fold lower) those reported in other works on rodents under controlled conditions. BM activity suggests that rainfall seem to exacerbate the effects of pesticides on mice; however, it seemingly does not pose a risk for their survival. The use of wild mice as bioindicators is a valuable and practical tool to detect disturbances derived from the use of pesticides in agricultural areas. Further research is recommended using a broader BM battery to identify those pollutants with the most severe effect on the physiology of wild animals incidentally exposed to pesticides. El uso de plaguicidas en cultivos aledaños a áreas de conservación, significa un riesgo para la fauna silvestre expuesta accidentalmente cuyos efectos son desconocidos, particularmente en la Península de Yucatán, México. Los ratones silvestres que habitan las regiones agrícolas, desempeñan un papel ecológico importante, además pueden servir como bioindicador de exposición a contaminantes. Los objetivos del presente trabajo fueron determinar la presencia de plaguicidas organoclorados (OC) en hígado y evaluar la exposición a partir de la respuesta temporal de los biomarcadores enzimáticos (BM), tales como acetilcolinesterasa (AChE), glutatión-S-transferasa (GST) y catalasa (CAT). Ratones silvestres (Mus musculus) fueron capturados entre junio de 2015 y abril de 2016 en un cultivo de sandía de una comunidad agrícola, en Quintana Roo, México. Los individuos fueron sacrificados in situ y se le diseccionaron los tejidos (hígado, cerebro y músculo esquelético). La presencia d...

show abstract

Section: Resultscontrasting

confidence: 66%

Presence of organochlorine pesticides and characterization of biomarkers in wild mice living in crop fields

Herrera

Escalona‐Segura

González-Jaurégui

et al. 2018

Therya

View full text Add to dashboard Cite

show abstract

“…Extensive data suggest that free radical formation and oxidative stress can be a major contributor to the toxicity of pesticides (108)(109)(110)(111)(112)(113). OPs are oxidants and impair enzymatic antioxidant defences, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione S-transferase (GST) (23,34,44,(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129). Malathion, methyl parathion, and parathion in HepG2 cell lines, as well as chlorpyrifos, methidathion, chlorfenvinphos, and dimethoate in rat liver and diazinon in fish most probably disrupt membrane lipids through oxidative stress (23,35,61,116,118,(130)(131)(132)(133)(134)(135).…”

Section: Possible Effects Of Ops On Hepatic Oxidative Stress Pathwaysmentioning

confidence: 99%

“…Several in vivo and in vitro studies reported that the genotoxicity of OPs such as dimethoate, methyl parathion, chlorpyrifos, phorate, and malathion in hepatocytes was associated with oxidative damage (130,131,127,(149)(150)(151)(152)(153)(154)(155)(156)(157)(158)(159). A study by Hreljac et al (160) showed that methyl paraoxon was less genotoxic in HepG2 cells than its parent OP methyl parathion.…”

Section: Possible Mutagenic Genotoxic and Carcinogenic Effects Of Opsmentioning

confidence: 99%

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Karami‐Mohajeri

Ahmadipour

Rahimi

et al. 2017

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

show abstract

“…Dimethoate (DM), one of the most popular organophosphorus insecticides, is frequently used against a wide range of insects in agriculture and for housefly control due to its high effectiveness (Priya et al, ; Ayed‐Boussema et al, ; Guo et al, ). The residue of DM and its analog have been found in soil, crops, water, and foods, including cow's milk (Amara et al, ; Soler et al, ; Feng et al, ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic toxicity of zno nanoparticles and dimethoate in mice: Enhancing their biodistribution by synergistic binding of serum albumin and dimethoate to zno nanoparticles

Yan

Guo

et al. 2016

Environmental Toxicology

View full text Add to dashboard Cite

The extensive applications of ZnO nanoparticles (nano ZnO) and dimethoate (DM) have increased the risk of humans' co-exposure to nano ZnO and DM. Here, we report the synergistic effect of nano ZnO and DM on their biodistribution and subacute toxicity in mice. Nano ZnO and DM had a synergistic toxicity in mice. In contrast, bulk ZnO and DM did not cause an obvious synergistic toxicity in mice. Although nano ZnO was low toxic to mice, coexposure to nano ZnO and DM significantly enhanced DM-induced oxidative damage in the liver. Coadministration of nano ZnO with DM significantly increased Zn accumulation by 30.9 ± 1.9% and DM accumulation by 45.6 ± 2.2% in the liver, respectively. The increased accumulations of DM and Zn in the liver reduced its cholinesterase activity from 5.65 ± 0.32 to 4.37 ± 0.49 U/mg protein and induced hepatic oxidative stress. Nano ZnO had 3-fold or 2.4-fold higher binding capability for serum albumin or DM, respectively, than bulk ZnO. In addition, serum albumin significantly increased the binding capability of nano ZnO for DM by approximately four times via the interaction of serum albumin and DM. The uptake of serum albumin- and DM-bound nano ZnO by the macrophages significantly increased DM accumulation in mice. Serum albumins play an important role in the synergistic toxicity of nano ZnO and DM. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1202-1212, 2017.

show abstract

Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication

Abstract: Our study demonstrated that DM induced DNA damage in the liver and kidney of treated mice in a dose-dependent manner; this induction was associated to DM-induced oxidative stress. Further investigations are needed to prove the implication of oxidative stress in genotoxicity induced by DM.

Cited by 19 publications

References 65 publications

Presence of organochlorine pesticides and characterization of biomarkers in wild mice living in crop fields

Presence of organochlorine pesticides and characterization of biomarkers in wild mice living in crop fields

Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

Synergistic toxicity of zno nanoparticles and dimethoate in mice: Enhancing their biodistribution by synergistic binding of serum albumin and dimethoate to zno nanoparticles

Contact Info

Product

Resources

About