Genotoxicity profiles in exfoliated human mammary cells recovered from lactating mothers in Istanbul; relationship with demographic and dietary factors

Yılmaz, Bayram; Sandal, Süleyman; Ayvaci, Habibe; Tuğ, Niyazi; Vitrinel, Ayça

doi:10.1016/j.mrgentox.2012.06.011

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…Cancer is one of the most important diseases that cause death in the world, and therefore, several research and development are carried out in order to develop new drug candidates with minimal side effects and high efficiency in the diagnosis and treatment of cancer. In this context, especially cinnamic acid and its derivatives have received great attention due to their potential as anti‐cancer agents [31–35] . It is one of the possible hypotheses that most of the anticancer drugs used in the clinic exert their effects through the inhibition of DNA‐bound proteins/enzymes or by interacting directly with DNA [36,37] .…”

Section: Resultsmentioning

confidence: 99%

Synthesis of New Cinnamoyl‐Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

Çalışkan

Öztürk

Koran

et al. 2022

Chemistry & Biodiversity

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Amino acid conjugates are described by the reaction of amino acids with bioactive organic groups such as vitamins, hormones, flavonoids, steroids, and sugars. In this study, 12 new conjugates were synthesized by reaction of cinnamic acid derivatives with various amino acids. Cytotoxic studies against four different human cancer cells (MCF7, PC‐3, Caco‐2, and A2780) were carried out by MTT assay method at five different concentrations. The structure‐activity relationships based on the cell viability rates were evaluated. To compare the anticancer activities of the compounds using computational chemistry methods, they were docked against A2780 human ovarian cancer, Michigan Cancer Foundation‐7 (MCF7), human prostate cancer (PC‐3) and human colon epidermal adenocarcinoma (Caco‐2) cell lines and compared with the standard 5‐Fluorouracil. The results indicate that the efficacy of cinnamic acid derivatives increases with the presence of amino acids. Comet assay was conducted to understand whether the cell deaths occur through DNA damage mechanism and the results exhibit that the changes in the specified parameters were statistically significant (p<0.05). Our study demonstrated that the compounds cause cell death through the formation of DNA damage mechanism.

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Section: Resultsmentioning

confidence: 99%

Synthesis of New Cinnamoyl‐Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

Çalışkan

Öztürk

Koran

et al. 2022

Chemistry & Biodiversity

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“…Further complicating the picture of breast cancer in Turkey are the changes in demographics and risk factors that occur as women adopt a more "Western" lifestyle. 27,28 Increased BMI, older age at first full-term pregnancy, and reduced breastfeeding have all been associated with increased breast cancer risk 27,29 and are considered part or consequences of the Western lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Promoter Methylation in Epithelial-Enriched and Epithelial-Depleted Cell Populations Isolated from Breast Milk

et al. 2014

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“…10 During the aging process, the most important impairment in the body is the DNA damage and it affects the molecular processes harmfully. [14][15][16] In addition to the entropy generation, organismal heat generation is also associated with double-strand breaks in the genetic material and segregation or aggregation of the proteins. 17 All the living beings die after generating a certain amount of lifespan entropy, since their bodies cannot stand accumulating more damage.…”

Section: Introductionmentioning

confidence: 99%

“…Entropy accumulation in the body reveals itself as structural damage, 13 it is regarded as a sign of aging and measured in terms of information entropy 10 . During the aging process, the most important impairment in the body is the DNA damage and it affects the molecular processes harmfully 14–16 . In addition to the entropy generation, organismal heat generation is also associated with double‐strand breaks in the genetic material and segregation or aggregation of the proteins 17 .…”

Section: Introductionmentioning

confidence: 99%

How much energy is needed to keep the stored cellular mass and energy free of errors: Case studies

Semerciöz

Özilgen

2022

Energy Storage

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Nobel‐winning scientist Erwin Schrödinger in his study “What is life?” (1934) hypothesized that organisms import energy and export entropy to survive. Since the publication of this study, our knowledge about “how entropy is generated within the body and exported” has increased tremendously. In the 1970s and 1980s, “maintenance energy” was used extensively in microbiological analyses, merely as a proportionality constant relating cellular proliferation to energy utilization. In 2015, Aziz Sancar, Tomas Lindahl, and Paul L. Modrich shared the Nobel prize for their studies regarding DNA repair. In these research works, scientists tried to explain how organisms were trying to reduce the entropy accumulated within their structures. This study assesses different cases of energy utilization by the cellular systems to maintain their reserves error free in the light of the recent findings. In every case, assessed huge energy requirements were found.

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Genotoxicity profiles in exfoliated human mammary cells recovered from lactating mothers in Istanbul; relationship with demographic and dietary factors

Cited by 8 publications

References 33 publications

Synthesis of New Cinnamoyl‐Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

Synthesis of New Cinnamoyl‐Amino Acid Conjugates and in Vitro Cytotoxicity and Genotoxicity Studies

Promoter Methylation in Epithelial-Enriched and Epithelial-Depleted Cell Populations Isolated from Breast Milk

How much energy is needed to keep the stored cellular mass and energy free of errors: Case studies

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