Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma

Puar, Troy; Berkel, Anouk van; Gotthardt, Martin; Havekes, Bas; Hermus, A.R.M.M.; Lenders, Jacques W.M.; Lichtenbelt, Wouter D. van Marken; Xu, Ying; Brans, Boudewijn; Timmers, Henri J L M

doi:10.1210/jc.2015-3205

Cited by 32 publications

(23 citation statements)

References 38 publications

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“…Increased FDG uptake, reflecting the activation of brown adipose tissues and beige coloration of white adipose tissues, disappeared after the right peritoneal paraganglioma was resected. β3‐adrenergic stimulation of adipocytes is known to increase glucose uptake both dependently and independently of mitochondrial activation, manifesting as high FDG accumulation . The present case demonstrated the potential of white adipose tissues to develop into beige adipose tissue by mitochondrial activation following β3‐adrenergic receptor stimulation in PPGL.…”

Section: Discussionsupporting

confidence: 50%

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Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Terada

Ashida

Ohe

et al. 2019

Clinical Case Reports

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In pheochromocytoma/paraganglioma, nontumorous high 18F‐fluorodeoxyglucose accumulations are observed in both beige and brown adipose tissues. Recognizing this feature of 18F‐fluorodeoxyglucose accumulation can help physicians make precise diagnoses and help them avoid the pitfalls of a false‐positive 18F‐fluorodeoxyglucose positron emission tomography result, preventing unnecessary interventions.

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Section: Discussionsupporting

confidence: 50%

“…High FDG accumulation has been reported in activated brown or beige‐colored white adipose tissue caused by catecholamines or cold exposure . Successful resection of PPGLs, resulting in amelioration of hyper‐catecholamine levels, leads to disappearance of high FDG accumulations in adipose tissues.…”

Section: Introductionmentioning

confidence: 99%

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Terada

Ashida

Ohe

et al. 2019

Clinical Case Reports

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“…Composite pheochromocytoma-ganglioneuroblastoma is an extremely rare tumor (1,(6)(7)(8)(9)(10)(11)(12), given this unusual association that sparked interest in reporting the case; we confirm its importance to be source of studies and possible new treatments.…”

Section: Considerationssupporting

confidence: 59%

A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma

Sousa¹,

Oliveira²,

Cortez³

et al. 2016

Acta Med. (Hradec Kralove, Czech Repub.)

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Pheochromocytoma and Ganglioneuroblastoma are separate diseases and a rare combination in which the diagnosis can only be confirmed by pathological examination after tumor excision. We reported here a case of ganglioneuroblastoma encapsulated in pheochromocytoma. The patient is a woman, 73 years old, hypertensive, with hypothyroidism, associated for 15 years with hypercholesterolemia and hypertriglyceridemia, which had frequent complaints of low back pain. She underwent magnetic resonance and the findings were consistent with the diagnosis of pheochromocytoma. After surgery, anatomic, pathologic and immunohistochemistry analysis confirmed the diagnosis of pheochromocytoma composed by small ganglioneuroblastoma representation with the identification of small focus of infiltration of the adrenal capsule and adipose tissue by pheochromocytoma. This rare association can instigate the discussion of methods of diagnosis, more effective and more appropriate treatments for each patient.

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“…Patients suffering from NE-producing adrenal gland tumors, so called pheochromocytomas, can exhibit massive browning of the adjacent visceral fat 27,31,32 . This is most pronounced in perirenal fat and strongly suggests that NE originating from the adrenal gland can induce adipose browning [33][34][35] . In the current study we therefore hypothesized that a multilocular BAT phenotype would exist close to local sources of sympathetic activation, i.e.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric perirenal brown adipose dormancy in adult humans is defined by local sympathetic activity

Jespersen

Feizi

Andersen

et al. 2018

Preprint

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We here detect dormant brown adipose tissue (BAT) in adult humans, occurring in most of the perirenal fat depot and characterized by a unilocular morphology. This phenotype was contrasted by multilocular BAT accumulating near the adrenal gland. Transcriptomic analysis revealed a gene expression profile of unilocular BAT that was approaching, yet was still distinct from, the expression profile of subcutaneous white adipose tissue (WAT). Candidate gene signatures were recapitulated in a murine model of unilocular brown fat induced by thermoneutrality and high fat diet. We identified SPARC as a candidate adipokine representing a dormant BAT state in the absence of sympathetic activation and CLSTN3 as a novel marker for multilocular BAT. Brown fat precursor cells were present in the entire perirenal fat depot, regardless of state. When differentiated in vitro, these cells responded to acute norepinephrine stimulation by increasing UCP1 gene expression and uncoupled respiration, confirming a BAT phenotype. We thus propose a mechanism for the reduction of functionally competent BAT in adult humans and we provide a solid data set for future research on factors that can reactivate dormant BAT as a potential strategy for combatting obesity and metabolic disease.

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Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma

Abstract: Patients with PGLs exhibit a high prevalence of BAT activation on (18)F-FDG PET/CT. This is likely due to systemic catecholamine excess. BAT activation is not associated with specific germline mutations.

Cited by 32 publications

References 38 publications

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma

Asymmetric perirenal brown adipose dormancy in adult humans is defined by local sympathetic activity

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Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma

Abstract: Patients with PGLs exhibit a high prevalence of BAT activation on (18)F-FDG PET/CT. This is likely due to systemic catecholamine excess. BAT activation is not associated with specific germline mutations.

Cited by 32 publications

References 38 publications

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma

Asymmetric perirenal brown adipose dormancy in adult humans is defined by local sympathetic activity

Contact Info

Product

Resources

About

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report

Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of ¹⁸F‐fluorodeoxyglucose in sporadic paraganglioma: A case report