Genotyping and susceptibility testing uncovers large azole-resistant Candida tropicalis clade in Alexandria, Egypt

Spruijtenburg, Bram; Meijer, Eelco F. J.; Xiao, Meng; Shawky, Sherine; Meis, Jacques F.; Groot, Theun de; El-Kholy, Mohammed A.

doi:10.1016/j.jgar.2023.06.012

Cited by 5 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the possibility of gradual resistance to fluconazole, the frequency of C. tropicalis detection in different clinical cases has become a cause of concern. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment

Amin Zadeh,

Zomorodkia,

Hadi

et al. 2024

Journal of Oral Biology and Craniofacial Research

View full text Add to dashboard Cite

“…Due to the possibility of gradual resistance to fluconazole, the frequency of C. tropicalis detection in different clinical cases has become a cause of concern. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment

Amin Zadeh,

Zomorodkia,

Hadi

et al. 2024

Journal of Oral Biology and Craniofacial Research

View full text Add to dashboard Cite

Short Tandem Repeat Genotyping of Medically Important Fungi: A Comprehensive Review of a Powerful Tool with Extensive Future Potential

Spruijtenburg,

Meis,

Verweij

et al. 2024

Mycopathologia

View full text Add to dashboard Cite

Fungal infections pose an increasing threat to public health. New pathogens and changing epidemiology are a pronounced risk for nosocomial outbreaks. To investigate clonal transmission between patients and trace the source, genotyping is required. In the last decades, various typing assays have been developed and applied to different medically important fungal species. While these different typing methods will be briefly discussed, this review will focus on the development and application of short tandem repeat (STR) genotyping. This method relies on the amplification and comparison of highly variable STR markers between isolates. For most common fungal pathogens, STR schemes were developed and compared to other methods, like multilocus sequence typing (MLST), amplified fragment length polymorphism (AFLP) and whole genome sequencing (WGS) single nucleotide polymorphism (SNP) analysis. The pros and cons of STR typing as compared to the other methods are discussed, as well as the requirements for the development of a solid STR typing assay. The resolution of STR typing, in general, is higher than MLST and AFLP, with WGS SNP analysis being the gold standard when it comes to resolution. Although most modern laboratories are capable to perform STR typing, little progress has been made to standardize typing schemes. Allelic ladders, as developed for Aspergillus fumigatus, facilitate the comparison of STR results between laboratories and develop global typing databases. Overall, STR genotyping is an extremely powerful tool, often complimentary to whole genome sequencing. Crucial details for STR assay development, its applications and merit are discussed in this review.

show abstract

Investigating the potential of thiazolyl carbohydrazides derivatives as anti-Candida albicans agents: An intuition from molecular modelling, pharmacokinetic evaluation, and molecular docking analysis

Benjamin,

Benson,

Adalikwu

et al. 2023

Chemical Physics Impact

View full text Add to dashboard Cite

Genotyping and susceptibility testing uncovers large azole-resistant Candida tropicalis clade in Alexandria, Egypt

Cited by 5 publications

References 48 publications

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment

Synthesis and evaluation of the antifungal activity of 5-hydroxy-3-phenyl-1H-pyrazole-1-carbothioamide for use in the oral environment

Short Tandem Repeat Genotyping of Medically Important Fungi: A Comprehensive Review of a Powerful Tool with Extensive Future Potential

Investigating the potential of thiazolyl carbohydrazides derivatives as anti-Candida albicans agents: An intuition from molecular modelling, pharmacokinetic evaluation, and molecular docking analysis

Contact Info

Product

Resources

About