Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections

Prior, Sandra; Gamazo, Carlos; Irache, Juan M.; Merkle, Hans P.; Gander, Bruno

doi:10.1016/s0378-5173(99)00448-2

Cited by 119 publications

(78 citation statements)

References 22 publications

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“…Mag-loaded in PCL nanocapsules were obtained by a multiple emulsion (W 1 /O/W 2 ) method adapted to this particular case [21]. Briefly, Mag was dispersed in 0.5 ml of an inner water phase containing 1% w/v sodium citrate by ultrasonication (Microson ultrasonic cell disruptor XL, Misonix, USA) for 1 min.…”

Section: Formulation Of Maghemite Loaded-pcl Nanocapsules (Magpcl-nc)mentioning

confidence: 99%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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Iron oxide nanoparticles (ION) have been studied for essential applications, like detection of biological constituents (virus, bacterials, cell, nucleic acids, protein, enzyme, etc.), magnetic bioseparation and clinic therapy and diagnosis (such as MRI magnetic fluid and hyperthermia). In this work, γ-Fe 2 O 3 has been synthetized by a adapted sol-gel method and entraped in poly ε-caprolactone (PCL) nanocapsules. The superparamagnetic nanocapsules have been formulated by double emulsion evaporation method. Some variables affecting the polydispersity index, zeta potential surface and size of nanocapsules were studied aiming optimize the formulation process of maghemite-loaded PCL nanocapsules. The following parameters were selected: sonication time, PCL concentration in organic phase, PVA concentration in external aqueous phase and maghemite/PCL weight ratio. Under these experimental conditions, the resulting nanocapsules displayed a mean size of about 346 nm and a maghemite content of about 7.5 µg/mg of nanocapsules and superparamagnetic behaviour at room temperature.

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Section: Formulation Of Maghemite Loaded-pcl Nanocapsules (Magpcl-nc)mentioning

confidence: 99%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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“…tetanus toxoid) [9], and antibiotics (e.g. gentamicin) [10,11] get degraded in the stomach while non-steroidal anti-inflammatory drugs (e.g. aspirin) [12,13] cause irritation of the gastric mucosa which might result in the ulceration [14].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of vegetable organogels for controlled delivery applications

Sagiri

Sethy

Pal

et al. 2012

Designed Monomers and Polymers

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The present study deals with the encapsulation of vegetable organogels in alginate microparticles (MPs). Mango butter (MB) and cocoa butter (CB) are natural organogels, which are being used in the preparation of pharmaceutical formulations. In addition to these, mustard oil (MO) was used as the control. The thermal stability of MB and CB can be enhanced by encapsulating them and can be used in oral drug-delivery formulations. Double emulsification method was followed for the preparation of MPs. By this method, spherical MPs were synthesized and the sphericity was confirmed by doing light microscopy and scanning electron microscopy. The size range of MPs was 107 ± 53 μm, 79 ± 43 μm, and 112 ± 78 μm for MPs encapsulating MO, MB, and CB, respectively. The melting endotherms of MPs with MB and CB were in exact match with the melting points of MB and CB. This confirmed the existence of MB and CB within the MPs. The encapsulation of the vegetable organogels altered the release pattern of the drug, metronidazole. The drug release kinetics suggested that the release pattern followed the non-Fickian kinetics. The MPs were found to be hemocompatible in nature and have shown good mucoadhesive and swelling properties. Based on the preliminary results, it was suggested that the vegetable organogels can be encapsulated in alginate MPs and used as drug-delivery vehicles.

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“…This effect could be attributed to the increase of the particle size which enable more drug to be incorporated into the microspheres. On the other hand, increasing the amount of GM in the initial emulsion to a value of 50 mg reduced the EE as described also by Prior et al, (2000). Finally, the highest EE was achieved when maintained W 1 at pH 6, where GM was more soluble (Table 2).…”

mentioning

confidence: 58%

“…In a previous work, Prior et al, (2000) found that GM loaded-microparticles prepared by spray-drying and using the uncapped Poly(D,L-lactide-co-glycolide) polymer (PLGA, RG 502H) showed a low burst and a continuous release profile. This property makes this formulation suitable as a possible therapy in brucellosis.…”

mentioning

confidence: 99%