Gentamicin-Loaded Thermosetting Hydrogel and Moldable Composite Scaffold: Formulation Study and Biologic Evaluation

Dorati, Rossella; Trizio, Antonella De; Merelli, Alessia Antonella; Modena, Tiziana; Conti, Bice

doi:10.1016/j.xphs.2017.02.031

Cited by 33 publications

(20 citation statements)

References 26 publications

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“…Shorter, 4-h complete drug release was reported by Dorati Fig. 7 SEM-EDX micrograph of DOX-30CaP@MSi pellet et al [45] who proposed gentamycin-loaded chitosan thermosetting hydrogels. In both publications, it has been claimed that obtained systems in vitro could exhibit potential antibacterial effect in the first stage of osteomyelitis treatment, due to the high local drug concentration provided in fast manner.…”

Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 85%

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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We reported the new biphasic composites of calcium phosphate and mesoporous silica material (CaP@MSi) in the form of powders and pellets as a potential bone drug delivery system for doxycycline hydrochloride (DOX). The CaP@MSi powders were synthesized by cationic surfactant-templating method. The effects of 10, 20, and 30% CaP content in the CaP@MSi powders on the molecular surface structure, the cytotoxicity against osteoblast cells in vitro, and the mineralization potential in simulated body fluid were investigated. The CaP@MSi characterized by the highest mineralization potential (30% CaP content) were used for DOX adsorption and pelletization process. The CaP which precipitated in the CaP@MSi composites was characterized as calcium-deficient with the Ca:P molar ratio between 1.0 and 1.2. The cytotoxicity assays demonstrated that the CaP content in MSi increases osteoblasts viability indicating the CaP@MSi (30% CaP content) as the most biocompatible. The combination of CaP and MSi was an effective strategy to improve the mineralization potential of parent material. Upon immersion in simulated body fluid, the CaP of composite converted into the bone-like apatite. The obtained pellets preserved the mineralization potential of CaP@MSi and provided the prolonged 5-day DOX release. The obtained biphasic CaP@MSi composites seem to have an application potential as bone-specific drug delivery system.

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Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 85%

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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“…In open orthopedic surgeries, gentamicin-loaded thermosetting composite hydrogels, which were prepared combining CS with bovine bone substitutes (Orthoss ® granules, Orange, CA, USA), beta-glycerophosphate as a cross-linker and lyophilized to obtain moldable composite scaffolds (moldable composite scaffold loaded with gentamicin [mCSG]), were considered to reduce the infection risks. 155 The hydrogels have broken the limit of gentamicin application since the effective dosage can be decreased. Other antibiotics with serious side effects can also be used with hydrogels.…”

Section: Gentamicinmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

319

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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“…Several authors investigated elution kinetics and antimicrobial effects of diverse antibiotics loaded into cements, bioglasses, and/or polymer systems [ 83 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 ]. Vancomycin, gentamicin, rifampicin, and moxifloxamicin showed excellent results with initial high elution rates followed by sustained elution rates for the entire experimental time, as well as keeping antimicrobial effect in situ.…”

Section: Osteomyelitis and Osteomyelitis Therapymentioning

confidence: 99%

“…The following section is dedicated to an example of research on the topic. Dorati and co-workers [ 116 , 117 , 118 ] carried out some research focused on the development of new biodegradable drug delivery systems combined to a biodegradable scaffold in order to locally administer gentamicin and promote prolonged release at infected tissue. Gentamicin is known to be a suitable antibiotic for osteomyelitis therapy; nevertheless, the high nephrotoxicity of gentamicin limits its use by systemic administration.…”

Section: Biodegradable Scaffold-drug Delivery Systems For Osteomyementioning

confidence: 99%

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

et al. 2017

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A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems. Some examples related to published studies on gentamicin sulfate-loaded drug-delivery systems combined with scaffolds are discussed, and future perspectives are highlighted.

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Gentamicin-Loaded Thermosetting Hydrogel and Moldable Composite Scaffold: Formulation Study and Biologic Evaluation

Cited by 33 publications

References 26 publications

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Antimicrobial hydrogels: promising materials for medical application

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

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