Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails

A Review on Biodegradable Polymeric Materials Striving Towards the Attainment of Green Environment

“…The improvement in crystallization rate and nucleation density of PLLA was observed, in which RCF fibers acted as a nucleation agent. Anna Morawska-Chochol et al (2014) [119] reported the development of novel, multiphase and multifunctional degradable intramedullary nails. Three different composites containing PLLA as matrix and carbon [120] followed polymer coagulation and salt-particle leaching method to fabricate porous PU composites reinforced with different concentration of bioglass.…”

Recent developments on intramedullary nailing: a biomechanical perspective

“…[108][109][110][111] Recent studies are already starting to show this tendency. [112][113][114][115] A promising product already in the market is the Expert Tibia Nail PROtect option, which offers protection from bacterial colonization through a local antibiotic prophylaxis coating while maintaining the same technique and instrumentation as the uncoated nails. However, bioactive coatings are still associated with challenges, such as penetration and diffusion barriers for antibiotic dissemination (e.g., tissue change due to inflammation or necrosis), the fact that even high doses of active substances may not always ensure adequate levels of effect, the high cost of growth factors, and the potential for ectopic bone formation caused by growth factures (not to mention the challenging regulatory pathway associated).…”

Bi-directional controlled release of ibuprofen and Mg2+ from magnesium alloys coated by multifunctional composite

“…To date, a number of magnesium based drug release orthopedic implant material have been reported, which focus on antibiotics, such as gentamicin [15], gentamicin sulfate [16], or antimicrobial peptide [17]. However, few research of anti-inflammatory drugs such as ibuprofen was reported.…”

“…However, few research of anti-inflammatory drugs such as ibuprofen was reported. At the same time, burst release phenomenon in initial stage is still a problem [15][16][17][18][19].…”