Genus Ruta: A natural source of high value products with biological and pharmacological properties

Coimbra, Alexandra; Ferreira, Susana; Duarte, Ana Paula

doi:10.1016/j.jep.2020.113076

Cited by 51 publications

(51 citation statements)

References 153 publications

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“…The families Fabaceae, Lamiaceae, Asteraceae, Apiaceae, Malvaceae, and Rutaceae were the most frequent and together constitute 35.0% (48/137) of the species used. These results are largely consistent with the results from other international ethnobotanical and ethnopharmacological studies, which not only highlight these families but also provide extensive documentation and a scientific assessment on the chemical composition and biological activity of the species grouped within them Abdelhafez et al, 2020;Abdul et al, 2020;Bhadane et al, 2018;Coimbra et al, 2020;Miara et al, 2019;Nisar et al, 2018;Sharifi-Rad et al, 2020;Suroowan et al, 2017). Two interesting aspects were identified: The 137 plant species used generally have an extensive distribution and habitat, and 50% of the commercialized products are composed of one to three plants.…”

Section: Resultssupporting

confidence: 87%

De acordo com o governador, a decisão vale para todos que estejam em condições físicas adequadas, mesmo os que ainda não tomaram a vacina contra a Covid-19

Coipel¹,

Odio²,

Álvarez³

et al. 2021

Braz. J. Vet. Res. Anim. Sci.

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The industrial manufacturing of natural products for veterinary use represents a major weakness in the veterinary sector despite increased interest and the traditional ancestral knowledge that supports them. A cross-sectional, descriptive observational study was conducted to characterize the veterinary herbal products marketed worldwide during 2018 and 2019. A comprehensive thematic search limited to the 2018-2019 period was performed in the ScienceDirect, Scopus, PubMed, Web of Science, ResearchGate, and Academic Search Complete databases. The investigation identified 487 products registered in the global market manufactured by 54 companies, led by India, The Netherlands, and the United Kingdom. The market segments of animal production and phytomedicines were dominant with 73.7% and 53.0% of products, respectively. Cattle (22.2%), sheep-goats (16.2%), and canines (16.2%) were the most favored species. The most represented therapeutic indications were those intended to treat gastrointestinal disorders (30.47%), antimicrobials (16.66%), and antiparasitic agents (10.47%). The families Fabaceae, Lamiaceae, Asteraceae, Apiaceae, Malvaceae, and Rutaceae stood out because of their frequent use, encompassing 35.0% of the 137 declared species. Andrographis paniculata (Burm.f.) Nees and Withania somnifera (Lin) Dunal were the most important species. Oral formulations for internal use (72%) and liquids (51%) in 100 mL, 500 mL, and 1 L presentations showed the highest prevalence on the market. The global market for veterinary herbal products during the 2018-2019 period was relevant in the productive and medical animal sector. No differences were found between medicinal plant species used to formulate herbal products for human and animal use.

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Section: Resultssupporting

confidence: 87%

De acordo com o governador, a decisão vale para todos que estejam em condições físicas adequadas, mesmo os que ainda não tomaram a vacina contra a Covid-19

Coipel¹,

Odio²,

Álvarez³

et al. 2021

Braz. J. Vet. Res. Anim. Sci.

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“…Ruta chalepensis is a medicinal plant used worldwide for its wide range of medicinal purposes [ 35 ]. However, the antiparasitic activity against Entamoeba histolytica of this plant has not been sufficiently disclosed in ethnobotanical reports until now.…”

Section: Discussionmentioning

confidence: 99%

Furanocoumarins from Ruta chalepensis with Amebicide Activity

et al. 2021

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Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

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“…In fact, various species of this genus have long been included in the European Pharmacopoeia. Traditional medicinal uses of Ruta species include their uses mainly as an abortifacient and emmenagogue and in the treatment of lung diseases and microbial infections ( Figure 1 ) [ 3 , 4 ]. Moreover, Ruta species have the potential for use as a potassium channel blocker in the treatment of neuromuscular diseases, anxiety, and dysmenorrhea.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, Ruta species have the potential for use as a potassium channel blocker in the treatment of neuromuscular diseases, anxiety, and dysmenorrhea. In addition to the presence of several bioactive alkaloids, coumarins (especially furanocoumarins), and flavonoids (mainly quercetin and its derivatives) in Ruta species, many of which are chemotaxonomically characteristic of the family Rutaceae, the species of this genus are also rich in essential oils, which contribute to their aromatic, agrochemical, and medicinal properties [ 4 , 5 , 6 ]. This review systematically evaluates and critically appraises the literature available to date on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief overview of the potential applications of nanotechnology and chitosan-based products of Ruta essential oils.…”

Section: Introductionmentioning

confidence: 99%

Ruta Essential Oils: Composition and Bioactivities

et al. 2021

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Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oils, which predominantly contain aliphatic ketones, e.g., 2-undecanone and 2-nonanone, but lack any significant amounts of terpenes. Three Ruta species, Ruta chalepensis L., Ruta graveolens L., and Ruta montana L., have been extensively studied for the composition of their essential oils and several bioactivities, revealing their potential medicinal and agrochemical applications. This review provides a systematic evaluation and critical appraisal of publications available in the literature on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief outlook of the potential applications of nanotechnology and chitosan-based products of Ruta essential oils.

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Genus Ruta: A natural source of high value products with biological and pharmacological properties

Cited by 51 publications

References 153 publications

De acordo com o governador, a decisão vale para todos que estejam em condições físicas adequadas, mesmo os que ainda não tomaram a vacina contra a Covid-19

De acordo com o governador, a decisão vale para todos que estejam em condições físicas adequadas, mesmo os que ainda não tomaram a vacina contra a Covid-19

Furanocoumarins from Ruta chalepensis with Amebicide Activity

Ruta Essential Oils: Composition and Bioactivities

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