Geographical distribution and phylogenetic analysis of Jingmen tick virus in China

Pang, Zengyuan; Jin, Yan; Pan, Mei Hung; Zhang, Yuli; Wu, Zhen; Liu, Lin; Niu, Guoyu

doi:10.1016/j.isci.2022.105007

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…They also demonstrated the existence of serological cross-reactivity between TBEV and KSIV, with the antibodies against these two viruses that could recognize each other’s antigens. JMTV was a novel segmented tick-borne flavivirus that had been reported in several provinces in China, it was first identified by high-throughput sequencing of ticks in Hubei Province in 2014 ( Qin et al, 2014 ; Guo et al, 2020 ; Yu et al, 2020 ; Pang et al, 2022 ; Zhang et al, 2022 ; Qu et al, 2023 ; Wu et al, 2023 ). JMTV was also found in several countries around the world.…”

Section: Resultsmentioning

confidence: 99%

Diversity of species and geographic distribution of tick-borne viruses in China

Wu,

Zhou,

Mao

et al. 2024

Front. Microbiol.

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IntroductionTick-borne pathogens especially viruses are continuously appearing worldwide, which have caused severe public health threats. Understanding the species, distribution and epidemiological trends of tick-borne viruses (TBVs) is essential for disease surveillance and control.MethodsIn this study, the data on TBVs and the distribution of ticks in China were collected from databases and literature. The geographic distribution of TBVs in China was mapped based on geographic locations of viruses where they were prevalent or they were detected in vector ticks. TBVs sequences were collected from The National Center for Biotechnology Information and used to structure the phylogenetic tree.ResultsEighteen TBVs from eight genera of five families were prevalent in China. Five genera of ticks played an important role in the transmission of TBVs in China. According to phylogenetic analysis, some new viral genotypes, such as the Dabieshan tick virus (DTV) strain detected in Liaoning Province and the JMTV strain detected in Heilongjiang Province existed in China.DiscussionTBVs were widely distributed but the specific ranges of viruses from different families still varied in China. Seven TBVs belonging to the genus Orthonairovirus of the family Nairoviridae such as Nairobi sheep disease virus (NSDV) clustered in the Xinjiang Uygur Autonomous Region (XUAR) and northeastern areas of China. All viruses of the family Phenuiviridae except Severe fever with thrombocytopenia syndrome virus (SFTSV) were novel viruses that appeared in the last few years, such as Guertu virus (GTV) and Tacheng tick virus 2 (TcTV-2). They were mainly distributed in the central plains of China. Jingmen tick virus (JMTV) was distributed in at least fourteen provinces and had been detected in more than ten species of tick such as Rhipicephalus microplus and Haemaphysalis longicornis, which had the widest distribution and the largest number of vector ticks among all TBVs. Parainfluenza virus 5 (PIV5) and Lymphatic choriomeningitis virus (LCMV) were two potential TBVs in Northeast China that could cause serious diseases in humans or animals. Ixodes persulcatus carried the highest number of TBVs, followed by Dermacentor nuttalli and H. longicornis. They could carry as many as ten TBVs. Three strains of Tick-borne encephalitis (TBEV) from Inner Mongolia Province clustered with ones from Russia, Japan and Heilongjiang Province, respectively. Several SFTSV strains from Zhejiang Province clustered with strains from Korea and Japan. Specific surveillance of dominant TBVs should be established in different areas in China.

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Section: Resultsmentioning

confidence: 99%

Diversity of species and geographic distribution of tick-borne viruses in China

Wu,

Zhou,

Mao

et al. 2024

Front. Microbiol.

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“…The JMTV positive rate in current study is substantially lower than the positive rates reported in both east neighboring provinces Fujian and Zhejiang Province ( 11 , 14 ). It is worth noticing that JMTV investigations of most provinces reported in China were positive except the investigation in Tibet, highlighting the wide spread of JMTV in China ( 33 ).…”

Section: Discussionmentioning

confidence: 98%

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Liu,

Hu,

Cao

et al. 2024

Front. Vet. Sci.

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Jingmen tick virus (JMTV) is a newly identified segmented flavivirus that has been recognized in multiple hosts, such as humans, buffalos, bats, rodents, mosquitos and ticks. Various clinical cases and studies manifested that JMTV is a true arbovirus with wide host spectrum and showed potential threats toward public health. JMTV has been reported in multiple countries in Asia, Europe, Africa, and America. Moreover, wild boars serve as an important intermediary between humans and the wild ecological system. In China, it has been reported in nine provinces, while the prevalence and the distribution of JMTV in most regions including Jiangxi Province are still unknown. Thus, to profile the distribution of JMTV in Jiangxi Province, an epidemiological investigation was carried out from 2020 to 2022. In current study, 66 ticks were collected from 17 wild boars in Jiangxi Province. The results showed that 12 out of 66 ticks were JMTV positive, indicating JMTV is prevalent in ticks and boars in Jiangxi Province. The genome sequences of JMTV strain WY01 were sequenced to profile viral evolution of JMTV in China. Phylogenetic analysis divided JMTV strains into two genotypes, Group I and Group II. WY01 belongs to Group II and it shares the closest evolutionary relationship with the Japan strains rather than the strains from neighboring provinces in China suggesting that JMTV might have complex transmission routes. Overall, current study, for the first time, reported that JMTV is prevalent in Jiangxi Province and provided additional information concerning JMTV distribution and evolution in China.

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“…This segmented genomic signature of JMTV has led to changes in the public understanding of flavivirus genome structure while revealing unexpected evolutionary links between non-segmented and segmented RNA virus genomes ( 3 ). The recent researches indicated that JMTV has been detected in a variety of arthropods, such as ticks, Culex pipiens , and Drosophila melanogaster , suggesting a wide host spectrum for JMTV ( 4 – 6 ). In addition, antibodies or genomes of JMTV have been successively detected in mammals such as cattle and bats, as well as in many rodents.…”

Section: Introductionmentioning

confidence: 99%

Jingmen tick virus: an emerging arbovirus with a global threat

Wu,

Zhang,

Zhang

et al. 2023

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Jingmen tick virus (JMTV), belonging to the Flaviviridae family, is a novel segmented RNA virus identified in 2014 in the Jingmen region of Hubei Province, China. Up to now, JMTV has been detected in a variety of countries or regions in Asia, Europe, Africa, and the Americas, involving a wide range of arthropods and mammals, and even humans. The JMTV genome is composed of four linear RNA segments, two of which are derived from flaviviruses, while the other two segments are unique to JMTV and has no matching virus. Currently, JMTV has been shown to have a pathogenic effect on humans. Humans who had been infected would develop viremia and variable degrees of clinical symptoms. However, the pathogenic mechanism of JMTV has not been elucidated yet. Therefore, it is crucial to strengthen the epidemiological surveillance and laboratory studies of JMTV.

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Geographical distribution and phylogenetic analysis of Jingmen tick virus in China

Cited by 7 publications

References 31 publications

Diversity of species and geographic distribution of tick-borne viruses in China

Diversity of species and geographic distribution of tick-borne viruses in China

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Jingmen tick virus: an emerging arbovirus with a global threat

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