Geographical Heterogeneity of Multiple Sclerosis Prevalence in France

Pivot, Diane; Debouverie, Marc; Grzebyk, Michel; Brassat, David; Clanet, M.; Clavelou, Pierre; Confavreux, Christian; Edan, Gilles; Leray, Emmanuelle; Moreau, Thibault; Vukusic, Sandra; Hédelin, Guy; Guillemin, Françis

doi:10.1371/journal.pone.0167556

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…Moreover, when compared to other western regions, the prevalence in Saudi Arabia is considered low. The prevalence in other western countries was reported as high as 98.4/100,000, 106.6/ 100,000, 170.9/100,000 and 179.9/100,000 in central Italy, Italy, France, Columbia and Canada respectively [19][20][21][22]. The variation in the prevalence could be related to many factors, for example genetic variation, certain environmental factors, role of ethnicity and other variations related to methodologies followed in the different studies; however, the increased prevalence is consistently reported across the different studies conducted globally and in neighboring countries.…”

Section: Discussionmentioning

confidence: 99%

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Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study

et al. 2020

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Background: In 2015, the first nationwide, multicenter Multiple Sclerosis (MS) registry was initiated in the Kingdom of Saudi Arabia (KSA) mainly with an objective to describe current epidemiology, disease patterns, and clinical characteristics of MS in Saudi Arabia. This article aimed to report initial findings of the registry and regional prevalence of MS. Method: In 2015, a national MS registry was launched in KSA to register all MS patient with confirmed diagnosis according to the 2010 McDonald Criteria. The registry aimed to identify and recruit all healthcare facilities treating MS patients in the Kingdom, and collect data such as demographics, clinical characteristics (disease onset, diagnosis, presentation of symptoms at onset, disease course, relapse rate, and disability measures), family history, and treatments. All the included sites have obtained IRB/EC approvals for participating in the registry. Currently, the registry includes 20 hospitals from different regions across the Kingdom. The Projected prevalence was calculated based on the assumption that the number of diagnosed MS cases in participating hospitals (in each region) is similar to the number of cases in remaining nonparticipant hospitals in the same region. Results: As of September 2018, the registry has included 20 hospitals from the different regions across the Kingdom and has collected comprehensive data on 2516 patients from those hospitals, with median age 32 (Range: 11-63) and 66.5% being females. The reported prevalence of MS for those hospitals was estimated to be 7.70/100,000 population and 11.80/100,000 Saudi nationals. Based on the assumption made earlier, we projected the prevalence for each region and for the country as a whole. The overall prevalence of MS at the country level was reported to be 40.40/100,000 total population and 61.95/100,000 Saudi nationals. Around 3 out of every 4 patients (77.5%) were 40 years of age or younger. Female to male ratio was 2:1. The prevalence was higher among females, young and educated individuals across all five regions of Saudi Arabia. Conclusion: The prevalence of MS has significantly increased in Saudi Arabia but is still much lower than that in the western and other neighboring countries like Kuwait, Qatar, and the UAE. However, compared to the past rates, Saudi Arabia's projected prevalence of MS through this national study is 40.40/100,000 population, putting the Kingdom above the low risk zone as per Kurtzke classification. The projected prevalence was estimated to be much higher among Saudi nationals (61.95/100,000 Saudi-nationals). The prevalence was higher among female, younger and educated individuals. Further studies are needed to assess the risk factors associated with increased prevalence in Saudi Arabia.

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Section: Discussionmentioning

confidence: 99%

“…20 King Fahad Specialist Hospital, Dammam, Qassim, Saudi Arabia. 21 King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia. 22 Itkan Health Consulting, Riyadh, Saudi Arabia.…”

Section: Fundingmentioning

confidence: 99%

Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study

et al. 2020

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“…The prevalence in other western countries was reported as high as 98.4/100,000, 106.6/100,000, 170.9/100,000 and 179.9/100,000 in central Italy, Italy, France, Columbia and Canada respectively. (19)(20)(21)(22) The variation in the prevalence could be related to many factors, for example genetic variation, certain environmental factors, role of ethnicity and other variations related to methodologies followed in the different studies; however, the increased prevalence is consistently reported across the different studies conducted globally and in neighboring countries. The female to male ratio in our study was 2:1 nearly similar to the two recent studies conducted in the MENA region, R. Alroughani et al and Hamdy et.…”

Section: Discussionmentioning

confidence: 99%

Rising Prevalence of Multiple Sclerosis in Saudi Arabia, a Descriptive Study

Jumah

Bunyan

Otaibi

et al. 2019

Preprint

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Introduction In 2015, the first nationwide, multi-center MS registry was initiated in Saudi Arabia mainly with an objective to describe current epidemiology, disease patterns, and clinical characteristics of MS in Saudi Arabia. This article aimed to report initial findings of the registry and regional prevalence of MS. Method The registry included patients with confirmed MS diagnosis according to the 2010 McDonald Criteria. It aimed to identify and recruit all healthcare facilities treating MS patients in the Kingdom, and collect data such as demographics, clinical characteristics, family history, and treatments. All included sites have obtained IRB/EC approvals for participating in the registry. Currently, the registry includes 20 hospitals from different regions across the Kingdom. The Projected prevalence was calculated based on the assumption that the number of diagnosed MS cases in participating hospitals (in each region) is similar to the number of cases in remaining nonparticipant hospitals in the same region. Results As of September 2018, the registry has included 20 hospitals and has collected comprehensive data on 2,516 patients from those hospitals, with median age 32(Range: 11-63) and 66.5% being females. The reported prevalence of MS for those hospitals was estimated to be 7.70/100,000 population and 11.80/100,000 Saudi nationals. Based on the assumption made earlier, we projected the overall prevalence of MS at the country level to be 40.40/100,000 population and 61.95/100,000 Saudi nationals. 77.5% were 40 years of age or younger. The prevalence was higher among females, young and educated individuals across all five regions of Saudi Arabia Conclusion The prevalence of MS has significantly increased in Saudi Arabia but is still much lower than that in the western and other neighboring countries like Kuwait, Qatar, and the UAE. However, compared to the past rates, Saudi Arabia’s projected prevalence of MS through this national study is 40.40/100,000 population, putting them above the low risk zone as per Kurtzke classification. The projected prevalence was estimated to be much higher among Saudi nationals (61.95/100,000 Saudi-nationals). The prevalence was higher among female, younger and educated individuals. Further studies are needed to assess the risk factors associated with increased prevalence in Saudi Arabia.

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“…This chronic disease is one of the most common causes of disability in young populations ( 2 ). In Europe, prevalence of MS is rising ( 3 ); however, geographical variations may be observed ( 4 , 5 ). It remains unclear whether this heterogeneity can be attributed exclusively to genetic and environmental factors, since access to healthcare and insurance policies varies across countries and may influence the results of prevalence studies performed on this continent.…”

Section: Introductionmentioning

confidence: 99%

The Administrative Prevalence of Multiple Sclerosis in Greece on the Basis of a Nationwide Prescription Database

et al. 2020

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Objective: To estimate current prevalence of multiple sclerosis (MS) in Greece using administrative data from the nationwide medicine prescription database. Methods: Prescription records of a 24-month period (June 2017–May 2019) were analyzed in order to identify cases of MS. Sex, age, and place of residence were recorded for each identified case. Prevalence of MS was calculated based on the updated records of the Greek population according to Hellenic Statistical Authority. Results: The 2-year cumulative period prevalence of MS was estimated to 197.8 per 100,000 (95% CI 197.6–198.0). In total, 21,218 patients (65.8% female) were identified. During this period, the prevalence of MS was 138.7 per 100,000 (95% CI 138.4–139.0) in men and 253.6 per 100,000 (95% CI 253.3–254.1) in women. Prevalence was higher in the 45–49 age group in both sexes. Analysis of the place of residence revealed higher prevalence in the Attica region and Western Greece while lower prevalence was observed in Northern Greece. No north–south latitude gradient was detected. Point prevalence on 1 January 2019 was calculated to 188.9 per 100,000 (95% CI 188.7–189.1). Regarding treatment, 73.1% of the identified cases received at least once a Disease Modifying Drug. Conclusions: According to this national-level study conducted in Greece, estimated prevalence of MS was found to be similar to those of other European countries. Heterogeneity of MS prevalence across the country was observed and needs further investigation.

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Geographical Heterogeneity of Multiple Sclerosis Prevalence in France

Cited by 17 publications

References 25 publications

Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study

Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study

Rising Prevalence of Multiple Sclerosis in Saudi Arabia, a Descriptive Study

The Administrative Prevalence of Multiple Sclerosis in Greece on the Basis of a Nationwide Prescription Database

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