Geometrical structures, thermal properties and antimicrobial activity studies of azodye complexes

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Polymer complexes of Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) were prepared by the reaction of 3‐allyl‐5‐[(4‐nitrophenylazo)]‐2‐thioxothiazolidine‐4‐one (HL) with metal ions. The structure of polymer complexes was characterized by elemental analysis, IR, UV–Vis spectra, X‐ray diffraction analysis, magnetic susceptibility, conductivity measurements and thermal analysis. Reaction of HL with Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) ions (acetate or chloride) give polymer complexes (1–5) with general stoichiometric [M(L)(O2CCH3)(H2O)2]n (where L = anionic of HL and M = Co(II) (1) or Ni(II) (2)), [Mn(HL)2(OCOCH3)2]n (3), [Cr(L)2(Cl)(H2O)]n (4) and [Cd(HL)(O2CCH3)2]n (5). The value of HOMO–LUMO energy gap (ΔE) for forms (A‐C) of monomer (HL) is 2.529, 2.296 and 2.235 eV, respectively. According to ΔE value, compound has minimum ΔE is the more stable, so keto hydrazone form (C) is more stable than the other forms (azo keto form (A), azo enol form (B)). The interaction between HL, polymer complexes of Co(II), Ni(II), Mn(II), Cr(III) and Cd(II) with Calf thymus DNA showed hypochromism effect. The HL and its polymer complexes were tested against some bacterial and fungal species. The results showed that the Cr(III) polymer complex (4) has more antibacterial activity than HL and polymer complexes (1–3 and 5) against Bacillus subtilis, Staphylococcus aureus and Salmonella typhimurium.

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Polymer complexes. LXXI. Spectroscopic studies, thermal properties, DNA binding and antimicrobial activity of polymer complexes

Diab

El‐Sonbati

Morgan³

et al. 2018

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“…On the other hand, a comparison between the antimicrobial activity of the azo dye ligand under study and its chelates and that of other reported azo dye ligands and their complexes indicated that the compounds reported here demonstrated, to some extent, higher activity against the same tested microbial strains . Other reported azo dye metal complexes exhibited higher activity comparing with the compounds under study …”

Section: Resultsmentioning

confidence: 50%

Synthesis, structural characterization and molecular modelling of bidentate azo dye metal complexes: DNA interaction to antimicrobial and anticancer activities

El‐Ghamry

Fathalla

Gaber

2017

A novel azo dye ligand, namely 1‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]naphthalen‐2‐ol (HL), was synthesized. Mn2+, Co2+, Ni2+, Cu2+ and UO22+ complexes were also prepared by the treatment of HL with Mn(CH3COO)2⋅4H2O, Co(CH3COO)2⋅4H2O, Ni(CH3COO)2⋅4H2O, Cu(CH3COO)2⋅H2O, CuCl2⋅2H2O, Cu(NO3)2⋅6H2O and UO2(NO3)2⋅6H2O. The structures of these metal chelates were confirmed using elemental, spectral, magnetic moment, molar conductance and thermal analyses. The analytical data confirmed the formation of the chelates in 1:1 (metal‐to‐ligand) ratio having the formula [ML(H2O)X]Y⋅H2O, where M is Mn2+, Co2+, Ni2+, Cu2+ or UO22+; X is Cl−, NO3− or CH3COO−; and Y is H2O. The azo compound acts in a monobasic bidentate manner via the nitrogen and oxygen atoms of azo and hydroxyl groups, respectively. All complexes were found to have tetrahedral structures, except the UO22+ complex that showed octahedral geometry. The mode of interaction between the synthesized complexes and calf thymus DNA was explored by the aid of absorption spectroscopy and viscosity measurements. The azo dye and its chelates were evaluated against the growth of various bacterial and fungal strains (Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Candida albicans) with insight gained into the effect of type of metal centre, type of coordinated anion and position of the metal in the periodic table on the activity of the complexes. The geometric structure of the complexes was optimized using molecular modelling. The in vitro cytotoxicity of the synthesized compounds was tested against HEPG2 cell line.

“…The Coats–Redfern and Horowitz–Metzger methods were employed graphically to evaluate the kinetic parameters. The thermal activation energy of decomposition E a , entropy Δ S *, enthalpy Δ H *, and Gibbs free energy change of the decomposition Δ G * were calculated as reported previously and are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

Polymer complexes. LXXII. Spectroscopic studies, thermodynamics, DNA binding and biological activity of polymer complexes

El‐Sonbati

Diab

Serag

2019

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A novel series of copper polymer complexes (1–4) were synthesized and characterized using various spectroscopic techniques. Spectra of all polymer complexes a tetragonal distorted geometry for the Cu(II) ion. The electronic spectra, magnetic moments and electron spin resonance results indicate tetragonal distortion geometry for the Cu(II) polymer complexes. The effects of various solvents on absorption spectra of the ligand are discussed. A prediction of the interaction of the ligand against anti‐cancer receptors was carried out using AutoDock server. The affinity of the compounds to calf thymus DNA was determined through UV–visible DNA binding titration, and intrinsic binding constant (Kb) was found to be 4.16 × 103, 3.10 × 105, 3.18 × 104 and 2.91 × 105 for polymer complexes 1–4, respectively. The antimicrobial activity of the polymer complexes against bacterial species (Bacillus cereus, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Enterococcus faecalis and Pseudomonas aeruginosa) and fungal species (Aspergillus niger, Fusarium oxysporum and Candida albicans) was investigated.