This study aims to assess the performance of the Global Change Observation Mission—Climate (GCOM-C) ETindex estimation algorithm to estimate the actual evapotranspiration (ETa) in southeastern Afghanistan. Here, the GCOM-C ETindex algorithm was adopted to estimate the monthly ETa for the period from November 2016 to October 2017 using a series of Landsat 8, Thermal Infrared Sensor (TIRS) Band 10 satellite imagery. The estimation accuracy was evaluated by comparing the results with other estimates of ETa, namely the mapping evapotranspiration with the internalized calibration (METRIC) model, the MODIS Global Evapotranspiration Project (MOD16), the surface energy balance system (SEBS) tools, and with the crop evapotranspiration under standard conditions (ETc) as estimated by the FAO-56 procedure. The evaluation was made for irrigated wheat, maize, rice, and orchards and for non-irrigated bare soil land. The comparison of ETa values showed good correlation among the GCOM-C, METRIC, and FAO-56, while the MOD16 and SEBS showed significantly lower values of ETa. The agreement with the METRIC ETa implies that the simple GCOM-C algorithm successfully estimated the ETa in the region and that the precision was similar to that of the METRIC. This study provides the first high-quality evapotranspiration data with the spatial resolution of Landsat Band 10 data for the southeastern part of Afghanistan. The estimation procedure is straightforward, and its results are anticipated to enhance the understanding of regional hydrology.