Gerbils, As Experimental Animals (Meriones unguiculatus): Is A Good Role Model for Leishmania major?

Bakırcı, Serkan; Bilgiç, Hüseyin Bilgin; Köse, Onur; Aksulu, Ayça; Hacılarlıoğlu, Selin; Karagenç, Tülin; Çavuş, İbrahim; Özbilgin, Ahmet

doi:10.5152/tpd.2015.4300

Cited by 11 publications

(3 citation statements)

References 22 publications

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“…Due to their size, ease of handling, and similarity to patterns found in humans (Eckmann, 2003; Araújo et al, 2008), the gerbil ( Meriones unguiculatus ) is a model already widespread in many parts of the world and well established for the study of various diseases such as giardiasis (Ventura et al, 2013), Helicobacter pylori infection and stomach cancer (Kodama, Murakami & Fujioka, 2004; Júnior et al, 2016), hearing disorders (Abbas & Rivolta, 2015), and more recently, as a good model for the study of visceralization of Leishmania major (Bakırcı et al, 2015). Li et al (2016), selectively bred a group of spontaneously hyperglycemic diabetic Mongolian gerbils and established a spontaneous diabetic gerbil line with insulin resistance and leptin resistance as well as decreased adiponectin level in the serum.…”

Section: Introductionmentioning

confidence: 99%

Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus)

Ventura

Fortes

Santiago

et al. 2017

PeerJ

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BackgroundNowadays, the number of obese people in the world has reached alarming proportions. During the expansion of adipose tissue, a number of functions such as activation and release of cytokines and hormones may be affected. This leads the body to a pro-inflammatory pattern, which may affect the proper functioning of many tissues. Thus, studying the mechanisms by which obesity induces physiological disorders is necessary, and may be facilitated by the use of animal models, in particular rodents. We sought to characterize the metabolic and adipose tissue changes resulting from a diet rich in fats and simple sugars in gerbils.MethodsWe divided 14 gerbils into two experimental groups that received a diet rich in simple carbohydrates and fats with 5,86 kcal/g (OB, n = 7) or a standard diet with 4.15 kcal/g (CT; n = 7) for 11 weeks. The animals had free access to water and food. The animal weight and food consumption were measured weekly. Blood, adipose tissue and liver of each animal were collected at the end of experiment. The following parameters were determined: cholesterol (COL), triglycerides (TGL) and glycemia (GLI) in the plasma; cytokines (IL-6, IL-10 and TNF-α) and hormones (adiponectin and leptin) in adipose tissue; activity of superoxide dismutase (SOD) and catalase (CAT), extraction and differentiation of fat and histology in liver.ResultsThe consumption of a diet rich in simple carbohydrates and fats led to increased total body weight and increased relative weights of liver and adipose tissue. In addition, we observed increased fasting glucose levels and circulating triglycerides, along with high TNF-α production in adipose tissue and increased total fat, cholesterol and triglyceride contents in the liver, contributing to higher intensity of hepatic steatosis. On the other hand, the animals of this group showed depletion in the enzyme activity of SOD and CAT in the liver, as well as reduction of IL-10 and adiponectin levels in adipose tissue.DiscussionHigh intake of saturated fat and simple carbohydrates establish the gerbil as an experimental model for the study of metabolic and hepatic abnormalities resulting from obesity.

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Section: Introductionmentioning

confidence: 99%

Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus)

Ventura

Fortes

Santiago

et al. 2017

PeerJ

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“…Comumente, roedores infectados com espécies causadoras de LT não apresentam alterações clínicas visíveis (Figura 2), e se mantem na forma assintomática, atuando assim, como reservatórios (ANDRADE et al, 2015;BAKIRCI et al, 2015). Embora, algumas áreas da pele dos roedores, possam estar visualmente integras, onde estas podem ter uma grande concentração de amastigotas de Leishmania sp.…”

Section: Referencial Teóricounclassified

Parasitos Gastrointestinais De Roedores E Suas Implicações Na Saúde Pública

Jesus¹,

Vidal²,

Santos³

et al. 2023

Multiplicidade Das Ciências Da Saúde, Volume 4

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Esta obra está licenciada com uma Licença Creative Commons Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo desta obra e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Section: Referencial Teóricounclassified

Aspectos Da Toxoplasmose E Tripanossomíase Em Animais E Sua Importância Em Saúde Única

Santos¹,

Santos²,

Silva³

et al. 2023

Multiplicidade Das Ciências Da Saúde, Volume 4

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Gerbils, As Experimental Animals (Meriones unguiculatus): Is A Good Role Model for Leishmania major?

Cited by 11 publications

References 22 publications

Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus)

Obesity-induced diet leads to weight gain, systemic metabolic alterations, adipose tissue inflammation, hepatic steatosis, and oxidative stress in gerbils (Meriones unguiculatus)

Parasitos Gastrointestinais De Roedores E Suas Implicações Na Saúde Pública

Aspectos Da Toxoplasmose E Tripanossomíase Em Animais E Sua Importância Em Saúde Única

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