Geriatric depression and its relation with cognitive impairment and dementia

Dillon, Carol; Tartaglini, María Florencia; Stefani, Dorina; Salgado, Pablo; Taragano, Fernando E.; Allegri, Ricardo

doi:10.1016/j.archger.2014.04.006

Cited by 27 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dementia prevalence can range from 5 to 10% among those aged ≥65 years [24,37,38]; furthermore, the CDR can identify dementia conversion rates [39,40]. Demented patients can also exhibit a depressed state [41,42,43]; in the pcb-Cohort, 123 individuals (21.6%) were GDS+ and had a CDR = 0.5 or ≥1.…”

Section: Discussionmentioning

confidence: 99%

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Rosa¹,

Henriques²,

Carvalho³

et al. 2016

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: Diagnosing dementia is challenging in many primary care settings, given the limited human resources and the lack of current diagnostic tools. With this in mind, a primary care-based cohort was established in the Aveiro district of Portugal. Methods: A total of 568 participants were evaluated using cognitive tests and APOE genotyping. Results: The findings revealed a dementia prevalence of 12%. A strong correlation between increasing Clinical Dementia Rating (CDR) scores and education was clearly evident. Other highly relevant risk factors were activities of daily living (ADL), instrumental ADL, aging, depression, gender, the APOE ε4 allele, and comorbidities (depression as well as gastrointestinal, osteoarticular, and neurodegenerative diseases). A hitherto unreported, significant correlation between gastrointestinal disease and high CDR score was clearly observable. Conclusions: This study shows the merit of carrying out a dementia screening on younger subjects. Significantly, 71 subjects in the age group of 50-65 years were flagged for follow-up studies; furthermore, these cases with a potentially early onset of dementia were identified in a primary care setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Rosa¹,

Henriques²,

Carvalho³

et al. 2016

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…Thus, findings regarding the neuropsychological and prognostic features of apathy and depression in MCI were inconsistent, and the overall picture is therefore cloudy. It also remains unclear which subtypes or characteristics of geriatric depression deteriorate cognition (Dillon et al, 2014).…”

Section: Psychological Symptoms In MCImentioning

confidence: 99%

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

2020

Front. Aging Neurosci.

202

157

View full text Add to dashboard Cite

Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study's objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy.Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy.Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

show abstract

“…Major depressive disorder is common in later life and associated with substantial disability and poor quality of life . Moreover, depression leads to significant morbidity and mortality, with estimates of an annual prevalence of 6.6% and a lifetime prevalence of 16.2% .…”

Section: Introductionmentioning

confidence: 99%

Investigating the relationship between age of onset of depressive disorder and cognitive function

Eraydin

Mueller

Corbett

et al. 2018

Int J Geriat Psychiatry

View full text Add to dashboard Cite

Objectives Depressive disorder is commonly associated with impaired cognitive function; however, it is unclear whether the age of onset of the first episode of depression, current depression severity, or historical severity of depressive episodes are associated with cognitive performance. Methods This study examined baseline cross‐sectional data from the ongoing online PROTECT study. A total of 7344 participants, 50 years or older, with a history of depression and no diagnosis of dementia were divided into three groups according to age of onset of their first depressive episode: early‐onset, midlife‐onset, and late‐onset. Performance on measures of visuospatial episodic memory, executive function, verbal working, and visual working memory were evaluated. Demographic and clinical characteristics such as age, education, and severity of symptoms during their worst previous depressive episode and current depression severity were included in multivariate regression models. Results The late‐onset depression group scored significantly lower on the verbal reasoning task than the early‐onset group while there were no significant differences found on the other tasks. Midlife‐onset depression participants performed better in the visual episodic memory task, but worse on the verbal reasoning task, than early‐onset depression participants. Current depression severity was negatively correlated with all four cognitive domains, while historical severity score was found to be significantly associated with cognitive performance on the verbal reasoning and spatial working memory tasks. Conclusions The most important indicator of cognitive performance in depression appears to be current, rather than historic depression severity; however, late‐onset depression may be associated with more executive impairment than an early‐onset depression.

show abstract

Geriatric depression and its relation with cognitive impairment and dementia

Cited by 27 publications

References 29 publications

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

Investigating the relationship between age of onset of depressive disorder and cognitive function

Contact Info

Product

Resources

About