Germ Cell, Mesenchymal, and Thymic Tumors of the Mediastinum

Billmire, Deborah F.

doi:10.1016/s1055-8586(99)70022-3

Cited by 27 publications

(13 citation statements)

References 43 publications

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“…In the paediatric age group the mediastinum is the second most common site for extragonadal GCTs (type I tumours), with the sacrococcygeal region being the most common site with up 45% of cases reported here. Approximately 7% of cases of paediatric GCTs arise in the mediastinum 16,20,26 . In adults the mediastinum is the most common site for extragonadal GCTs and these are commonly seen in the third to fifth decades.…”

Section: General Remarksmentioning

confidence: 99%

“…17,20 Overall, GCTs account for 1-20% of mediastinal cysts and tumours. 16,[21][22][23][24][25] In the paediatric age group the mediastinum is the second most common site for extragonadal GCTs (type I tumours), with the sacrococcygeal region being the most common site with up 45% of cases reported here. Approximately 7% of cases of paediatric GCTs arise in the mediastinum.…”

Section: Tumour Types Germ Cell Tumoursmentioning

confidence: 99%

“…Approximately 7% of cases of paediatric GCTs arise in the mediastinum. 16,20,26 In adults the mediastinum is the most common site for extragonadal GCTs and these are commonly seen in the third to fifth decades. These tumours are exclusively type II, and with rare exceptions are encountered in men.…”

Section: Tumour Types Germ Cell Tumoursmentioning

confidence: 99%

“…Although thymic cysts and granulomatous diseases are usually reactive in nature, on occasion these may mimic or result from neoplastic disease and will enter the differential diagnosis. This review is written from a pathologist’s perspective; several excellent reviews on the specific entities with their differential diagnoses in and around the thymus approached from a more clinical viewpoint are available for additional information and further reading 7,11–17 . Specific disease entities are discussed first, followed by an approach to pathological diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…This review is written from a pathologist's perspective; several excellent reviews on the specific entities with their differential diagnoses in and around the thymus approached from a more clinical viewpoint are available for additional information and further reading. 7,[11][12][13][14][15][16][17] Specific disease entities are discussed first, followed by an approach to pathological diagnosis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Bakker

Oosterhuis

2009

Histopathology

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Masses within the thymus and mediastinum are frequently biopsied to establish a diagnosis. The specimens sent for histopathological analysis are typically small (needle) biopsy specimens on which the pathologist is challenged to provide a classifying diagnosis. Despite the fact that the pathology of the anterior mediastinum is predominantly centred on the thymus and it thus might be expected that the range of possible diagnoses is limited, the list of disease entities is in fact extensive, encompassing hyperplastic conditions and both benign and malignant neoplasms. In addition to primary thymic epithelial tumours, a number of less common diseases typical for this location may be encountered, including extragonadal germ cell tumours, lymphomas, soft tissue tumours and a number of conditions which may simulate a tumour, such as cysts and inflammatory conditions. In this review, the disease entities that may be encountered in biopsy material from anterior mediastinal/thymic processes are discussed and an approach to tackle the differential diagnosis is provided.

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Section: General Remarksmentioning

confidence: 99%