Gestão Da Qualidade Total: Percepções Dos Colaboradores Sobre a Necessidade Da Implantação De Procedimento Operacional Padrão Na Unidade De Pesquisa De Um Hospital Público Em Joinville/Sc

Júnior, Fernando Soares da Rocha

doi:10.29327/14941.15-23

Anais Do(a) XV ENFOC - Encontro De Iniciação Científica, XIV Fórum Científico, VI Seminário PIBID - Programa Institucional De B 2019

DOI: 10.29327/14941.15-23

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Gestão Da Qualidade Total: Percepções Dos Colaboradores Sobre a Necessidade Da Implantação De Procedimento Operacional Padrão Na Unidade De Pesquisa De Um Hospital Público Em Joinville/Sc

Fernando Soares da Rocha Júnior¹

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2020

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Histological classification and expression of markers of canine mast cell tumors

et al. 2020

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Background and Aim: Mast cell tumors (MCTs) are malignant neoplasms that are common in dogs. Their biological behavior is variable and unpredictable. The aim of the present study was to analyze the histological classification and expression of markers of canine MCTs. Materials and Methods: Thirty samples of canine MCTs were graded according to the histological classification methods of Patnaik and those of Kiupel. The expression of phosphoprotein 53 (p53) and c-kit proteins was quantified by immunohistochemistry using image processing software, ImageJ - a public domain computer program, developed at the National Institutes of Health. Results: It was possible to determine the grade of 100% of the samples. According to Patnaik's classification, 20.00% of the samples were Grade 1, 43.30% were Grade 2, and 36.70% were Grade 3. According to Kiupel's classification, 56.67% of the samples were of high intensity and 43.33% were of low intensity. Grade 1 tumors had the highest expression of p53 and c-kit, and Grade 2 had the lowest expression. The results showed that it is necessary to perform both histological grading methods. The classification into high and low intensity may provide more consistent results than the three-level grading system. However, a smaller number of categories, although it facilitates the classification, may not be sufficient for the prognosis. Conclusion: Quantitative evaluation of p-53 and c-kit expression is a useful tool to increase the accuracy of the analysis and to aid in choosing the treatment method for canine MCTs. Histological grading should be combined with other diagnostic methods.

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Histological classification and expression of markers of canine mast cell tumors

et al. 2020

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Gestão Da Qualidade Total: Percepções Dos Colaboradores Sobre a Necessidade Da Implantação De Procedimento Operacional Padrão Na Unidade De Pesquisa De Um Hospital Público Em Joinville/Sc

Cited by 1 publication

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Histological classification and expression of markers of canine mast cell tumors

Histological classification and expression of markers of canine mast cell tumors

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