Gestational and postnatal age associations for striatal tissue iron deposition in early infancy

Cabral, Laura; Calabro, Finn; Rasmussen, Jerod; Foran, Will; Moore, Lucille A; Graham, Alice M.; O’Connor, Thomas G.; Wadhwa, Pathik D.; Entringer, Sonja; Fair, Damien A.; Buß, Claudia; Panigrahy, Ashok; Luna, Beatríz

doi:10.1016/j.dcn.2023.101286

Cited by 4 publications

(2 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Characterizing age-related associations using these measures provides us with the structure to understand neonatal change, allowing us to examine change with the length of exposure to the postnatal environment or overall linear change with development. However, as described in Cabral et al 2023, additional work is needed to assess how brain development is uniquely impacted by gestation and subsequently altered by going from prenatal to postnatal life, where the brain rapidly changes as a response to postnatal stimulation. The perinatal variability associated with this switch has not been fully characterized.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multivariate and Regional Age-Related Change in Basal Ganglia Iron in Neonates

Cabral

Calabro

Foran

et al. 2023

Preprint

View full text Add to dashboard Cite

In the perinatal period, reward and cognitive systems begin trajectories, influencing later psychiatric risk. The basal ganglia is critical for reward and cognitive processing but early development is understudied. To assess age-related development, we used a measure of basal ganglia physiology, specifically brain tissue iron, obtained from nT2* signal in rsfMRI, linked to dopaminergic processing. We used data from the Developing Human Connectome Project (N=464) to assess how moving from the prenatal to the postnatal environment affects rsfMRI nT2*, modeling gestational and postnatal age separately for basal ganglia subregions in linear models. We didn't find associations with tissue iron and gestational age [Range:24.29-42.29] but found positive associations with postnatal age [Range:0-17.14] in the pallidum and putamen, but not the caudate. We tested if there was an interaction between preterm birth and postnatal age, finding early preterm infants (GA<35 weeks) had higher iron levels and changed less over time. To assess multivariate change, we used support vector regression to predict age from voxel-wise nT2* maps. We could predict postnatal but not gestational age when maps were residualized for the other age term. This provides evidence subregions differentially change with postnatal experience and early preterm birth may disrupt trajectories.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Our previous work early infancy (PMA at scan: range 39.71-48.57 weeks) examined these relationships, with separate terms for gestational and postnatal age (Cabral et al 2023). We found that postnatal age was significantly associated with an indirect measure of iron in the putamen and pallidum, but not the caudate.…”

Section: Introductionmentioning

confidence: 99%

Multivariate and Regional Age-Related Change in Basal Ganglia Iron in Neonates

Cabral

Calabro

Foran

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Assessment of fetal cardiac function in pregnant women with anemia: prospective case–control study

Agaoglu,

Tanacan,

Gurbuz

et al. 2024

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

ObjectiveTo compare the fetal cardiac functions between pregnant women with iron deficiency anemia (IDA) and healthy controls.MethodsThis single‐center, prospective, case‐control study was conducted at a tertiary hospital. A total of 150 patients, including 50 patients with IDA and 100 healthy pregnant women at 30‐34 weeks of gestation, were included in the study. Of the patients with anemia, 20 had mild anemia, 18 had moderate anemia, and 12 had severe anemia. Pulsed‐wave Doppler, M‐mode, and tissue Doppler imaging (TDI) were performed to evaluate fetal cardiac functions. The fetal cardiac score was calculated using the systolic, diastolic, and global hemodynamic function parameters.ResultsThe myocardial performance index and isovolumetric relaxation time were significantly higher in the IDA group than the control group, while isovolumetric contraction time was similar. Among the tricuspid and mitral valve diastolic parameters, the E, A, and E/A values were significantly lower in the IDA group (p<0.001). Mitral and tricuspid annular plane systolic excursions (MAPSE and TAPSE, respectively) were significantly lower in the IDA group (p<0.001). The IDA group also had significantly lower values for the TDI parameters, mitral and tricuspid E', A', S', E'/A' and a significantly higher E/E’ ratio (p<0.001). Upon examination of anemia subgroups, a significant decrease was observed in the tricuspid and mitral A, E, and E/A in those with severe anemia (p<0.001). M‐mode Doppler analysis revealed significantly lower TAPSE and MAPSE in the patient group with severe anemia. According to the subgroup comparison of TDI findings, the patients with severe anemia had significantly lower tricuspid and mitral E’, A’, S’ and E’/A’ (p<0.001) values and a significantly higher E/E’ ratio (p<0.001). The fetal cardiac score was significantly higher in the maternal IDA group compared to the control group. A significant negative correlation was found between maternal hemoglobin level and fetal cardiac score (p<0.001).ConclusionsThere may be changes in the systolic and diastolic cardiac functions of the fetuses of pregnant women with IDA. This study showed an increased E/E’ ratio in the fetuses of pregnant women with IDA, suggesting a decrease in fetal heart maturation. Within the IDA group, fetal cardiac functions were more affected in those with severe anemia.This article is protected by copyright. All rights reserved.

show abstract