Gestational gigantomastia

Abstract

A case of massive hypertrophy of the breasts in pregnancy was seen in our institution, which is a tertiary referral centre for the United Arab Emirates region with a delivery rate of 7000/year. It is a very rare condition (1 in 100000) and the only case seen in our hospital over the past 20 years. No similar case has been reported from the United Arab Emirates or Gulf regions, to our knowledge. The patient presented at a gestational age of 18 weeks on account of progressive swelling of the breasts which started at 14 weeks' gestation. In pregnancy she was managed conservatively with analgesics, bromocriptine and breast support. She had bilateral reduction mammoplasty 1 year after delivery. The outcome was satisfactory, and the patient was pleased with the cosmetic result.

Bilateral Gigantomastia, Multiple Synchronous Nodular Pseudoangiomatous Stromal Hyperplasia Involving Breast and Bilateral Axillary Accessory Breast Tissue, and Perianal Mammary-Type Hamartoma of Anogenital Mammary-Like Glands

“…Similar histological changes have been reported previously in gestational gigantomastia along with glandular hyperplasia, fibroadenoma, PASH, and chronic inflammatory changes. 23,29,35,36 The histopathological diagnosis of the nodular fibroepithelial proliferations that occurred in bilateral axillae and right breast in association with this patient's second pregnancy posed several problems. All lesions had an identical morphology and presented almost synchronously at the end of the second trimester of the second pregnancy.…”

Gestational Gigantomastia Complicating Pregnancy: A Case Report and Review of the Literature

“…Secondary infection (e.g., puerperal mastitis, pyogenic abscess) and sepsis may also occur in the absence of appropriate medical treatment [ 6 , 19 , 20 , 39 , 40 ]. Apart from physical complications, patients are often ostracized due to their physical appearance and suffer psychological trauma, depression, and sociophobia [ 3 , 5 – 8 , 10 ].…”

“…Since his initial description, approximately 100 cases have been reported in the literature [ 4 , 6 , 7 ]. The incidence of GG has been reported to be between 1 in 28,000 and 1 in 100,000 pregnancies between the years of 1935–1960 [ 2 , 6 ] and 1989–2009, respectively [ 8 – 10 ]. Gigantomastia usually affects both breasts, but it may occur unilaterally and, in some cases, may persist beyond pregnancy [ 9 , 11 – 13 ].…”

Gestational gigantomastia on a Saudi woman: A case report on surgical removal and reconstruction and management of complications, KFSH&RC

“…As of the moment, there are also limited options in the medical management of gestational gigantomastia. Bromocriptine is used as the main pharmacological intervention for GG [ 10 ]. It is known to halt the excessive and fast growth rate of the breasts, but further studies need to be conducted to determine if can actually cause regression.…”