Gestational Trophoblastic Disease with Painful Skin Metastases

Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor

“…Although ETT displays an unpredictable but usually benign and indolent behavior in most instances [1,5,6], metastases and death occur in approximately 25% and 10% of patients, respectively [6,8]. Epithelioid trophoblastic tumor is relatively chemotherapy resistant and surgical resection is the primary treatment modality [2].…”

“…Gestational trophoblastic disease (GTD) represents a spectrum of interrelated placental trophoblastic lesions, which can be further classified into benign and malignant [1,2]. Epithelioid trophoblastic tumor (ETT), first described in 1998 [3], is the most recent addition to GTD.…”