Getting to know your neighbor: Cell polarization in early embryos

Nance, Jeremy

doi:10.1083/jcb.201407064

Cited by 74 publications

(52 citation statements)

References 83 publications

(140 reference statements)

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“…During embryonic inner mass development, YAP cellular localization pattern impacts signaling molecules that control cell polarity and cell-cell crosstalk (Figure 2). The less compacted cells with nuclear YAP localization, give rise to the trophoectoderm while the more compacted cells in the inner cell mass show cytoplasmic localization of YAP [15,[30][31]. This is somewhat reminiscent of observations during malignant progression [7]: YAP cellular localization regulates the invasive capability of cancer cells and cancer cells forming lung metastases at the endothelial boundary of blood vessels showed nuclear YAP staining in contrast to cells distant from the endothelial invasion zone (Figure 2).…”

Section: Special Report Sharif and Wellsteinmentioning

confidence: 85%

Cell Density Regulates Cancer Metastasis Via the Hippo Pathway

Sharif

Wellstein

2015

Future Oncol.

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Metastatic spread of cancer cells from the primary tumor site to distant organs is the major cause of death in cancer patients. To disseminate, cancer cells detach from the primary tumor, enter the blood stream and extravasate at distant organ sites such as the liver, lung, bone or brain. While cancer cells are known to evade contact inhibition during growth in culture, we found that cell density is still sensed and can signal through the Hippo pathway effectors LATS1 and YAP. These effectors control cancer cell invasive behavior into stromal tissues, expression of cytokines that recruit inflammatory cells and progression toward metastatic spread. In this perspective, we discuss the drivers and the significance of pathways controlled by cell growth density.

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Section: Special Report Sharif and Wellsteinmentioning

confidence: 85%

Cell Density Regulates Cancer Metastasis Via the Hippo Pathway

Sharif

Wellstein

2015

Future Oncol.

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“…Fetus, being very similar to tumoral cells as far as differentiation, is the something that comes to my mine. So in embryology the polarization and migration are fundamental facts in development of embrions (Segmentation, polarized migration) [3]. I'm sure you can see where this is going.…”

Section: Introductionmentioning

confidence: 99%

“…To sum it up, the regenerative process includes three critical steps [3]: irstly, quiescent hepatocytes convert from G0 to G1 of the cell cycle when faced with multiple stimulations (the priming phase); secondly, with the help of mitogens, hepatocytes progress beyond the restriction point to the G1 phase and then the mitosis (the proliferation phase); and then the last, cells terminate proliferation under the control of negative factors (the termination phase), such as transforming growth factor beta (TGF-β) and activin . In these three phases, various cytokines or growth factors exhibit a pivotal role through cell signaling pathways of multiple biological effects" [14].…”

mentioning

confidence: 99%

“…Although polarity can be established through distinct upstream mechanisms in Caenorhabditis elegans, Xenopus laevis, and mouse embryos, in each species, it results in the restriction of PAR polarity proteins to contact-free surfaces of blastomeres. In turn, PAR proteins in luence cell fates by affecting signaling pathways, such as Hippo and Wnt, and regulate morphogenetic movements by directing cytoskeletal asymmetries [3]".…”

mentioning

confidence: 99%

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Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?

Luisetto¹

2018

Insights Biol Med

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According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more possible to introduce new therapeutic strategies to delay or in some cases even to stop this kind of killer process. Breast cancer, as an example, produces metastasis to different organs, which seems to be related to the subtype. We believe that a deep understanding of the roles of breast cancer cells and their interactions with the liver microenvironment in early breast cancer metastasis could be a crucial factor for the design and development of effective BCLM breast cancer liver metastases therapeutic strategies and to better understand the general process. Let's suppose the secondary organ or organs can be considered as incubator/s for the primary metastatic cells. What kind of consequences we can have in therapy fi eld if there is an active regulating role in determining the location of secondary cancers?Let's observe the role played by liver, bone marrow, CNS central nervous system, lungs, lymphocytes and other secondary locations/organs a little bit closer or maybe from a different angle let's suppose we try to come up with just a hypothesis. Just let's take this as a possibility, and we take the thread to see where it takes us.

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“…During early embryogenesis, descendent of the totipotent zygote (the 1-cell embryo that formed by sperm-egg fusion) gradually lose their developmental potential and acquire specific cell fate. Understanding the molecular inner works that underlie the regulation of cell fate determination during early embryogenesis has been one of the central issues in developmental biology (Johnson 2009, Rossant & Tam 2009, St Johnston & Ahringer 2010, Nance 2014, Du et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Unequal distribution of 16S mtrRNA at the 2-cell stage regulates cell lineage allocations in mouse embryos

Zheng

Zhang

et al. 2016

Reproduction

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Cell lineage determination during early embryogenesis has profound effects on adult animal development. Pre-patterning of embryos, such as that of Drosophila and Caenorhabditis elegans, is driven by asymmetrically localized maternal or zygotic factors, including mRNA species and RNA binding proteins. However, it is not clear how mammalian early embryogenesis is regulated and what the early cell fate determinants are. Here we show that, in mouse, mitochondrial ribosomal RNAs (mtrRNAs) are differentially distributed between 2-cell sister blastomeres. This distribution pattern is not related to the overall quantity or activity of mitochondria which appears equal between 2-cell sister blastomeres. Like in lower species, 16S mtrRNA is found to localize in the cytoplasm outside of mitochondria in mouse 2-cell embryos. Alterations of 16S mtrRNA levels in one of the 2-cell sister blastomere via microinjection of either sense or antisense RNAs drive its progeny into different cell lineages in blastocyst. These results indicate that mtrRNAs are differentially distributed among embryonic cells at the beginning of embryogenesis in mouse and they are functionally involved in the regulation of cell lineage allocations in blastocyst, suggesting an underlying molecular mechanism that regulates pre-implantation embryogenesis in mouse.

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Getting to know your neighbor: Cell polarization in early embryos

Cited by 74 publications

References 83 publications

Cell Density Regulates Cancer Metastasis Via the Hippo Pathway

Cell Density Regulates Cancer Metastasis Via the Hippo Pathway

Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?

Unequal distribution of 16S mtrRNA at the 2-cell stage regulates cell lineage allocations in mouse embryos

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