Gewebsatmung und Kationenmilieu

Studies on the Exchange of Potassium between Tumour Cell and Medium

“…Potassium Exchange and Energy-metabolism: As was mentioned in the beginning of this paper, the investigations considered were suggested by the results of researches on the influence of potassium and calcium upon the energy-metabolism of the tumour cell, in particular its fermentation capacity (2)(3)(4)(5)(6)(7)(8). With Jensen rat sarcoma and Flexner-Jobling rat carcinoma, it had been shown that the anaerobic fermentation depended to some extent upon the presence of potassium and calcium in the medium, the increase caused by the two cations being greater than that caused by a single one.…”

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The present paper deals with the manner in which the exchange of potassium between tumour cell and medium is effected, and the means by which it may be controlled, a subject which appears to be of importance in view of the rOle of potassium in the life processes within the tumour cell. The investigation was suggested by the results of research on the influence of potassium and calcium upon the energy-metabolism, especially the fermentation capacity, of tumours (2)(3)(4)(5)(6)(7)(8).

METHODSThe experiments were performed in vitro, and the general conditions were, as far as possible, the same as those employed in the metabolism experiments mentioned.Tumour Material: Jensen rat sarcoma was used, being particularly suitable as it contains little stroma. The tumours were produced in the usual way, by subcutaneous implantation of minced tumour tissue in adult rats.Treatment of the Tissue: In each experiment a tumour, removed immediately after the animal had been killed, was divided into several portions, the peripheral areas of which were cut, by means of a razor, into a fairly large number of thin slices.

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“…The present paper deals with the manner in which the exchange of potassium between tumour cell and medium is effected, and the means by which it may be controlled, a subject which appears to be of importance in view of the rOle of potassium in the life processes within the tumour cell. The investigation was suggested by the results of research on the influence of potassium and calcium upon the energy-metabolism, especially the fermentation capacity, of tumours (2)(3)(4)(5)(6)(7)(8). METHODS The experiments were performed in vitro, and the general conditions were, as far as possible, the same as those employed in the metabolism experiments mentioned.…”