Ghost Cell Odontogenic Tumor Associated with Odontoma - Report of Two Rare Cases

Abstract

The ghost cell odontogenic tumor (GCOT) is a neoplastic/cystic lesion with a diverse histopathological and clinical behavior. It was formerly known as calcified odontogenic cyst, but in 2005 the World Health Organization categorized this lesion as an odontogenic, benign tumor rather than a cyst; nominating this neoplasm as calcifying cystic odontogenic tumor. A later comprehensive classification named it ghost cell odontogenic tumor, because the most remarkable histopathologic characteristic is the presence of a mass of ghost cells embedded in the epithelium. We report two cases of a rare variant of a ghost cell odontogenic tumor associated with odontoma; to our knowledge, one is the youngest patient (four month old) reported in the English literature.

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

“…A clear cell GCOT variant was reported without further attempt at classification 57. It showed glycogen sheets and islands containing clear epithelial cells separated by a thin fibrous connective tissue stroma.…”

Cisto ósseo traumático associado a odontoma composto: relato de um caso incomum

“…Várias lesões podem se desenvolver associadas aos odontomas. O tumor odontogênico ade-nomatoide, o cisto odontogênico calcificante, o tumor odontogênico de células fantasmas e o cisto do ducto nasopalatino podem estar associados à lesão [22][23][24][25] . No presente caso, o OC mostrou-se associado à COT, fato este incomum e não relatado previamente na literatura.…”

Remoção cirúrgica de odontoma composto em maxila com achado tomográfico sugestivo de cisto do ducto nasopalatino

“…Após a remoção total da lesão mesmo apresentando pouco suporte ósseo, os elementos dentários envolvidos foram preservados, visto que a literatura apresenta maior taxa de sucesso em pacientes jovens 12 . Os odontomas podem acometer simultaneamente a outras patologias como cisto dentígeno, tumor odontogênico de células fantasmas 17 , tumor odontogênico adenomatóide 18 e cisto odontogênico calcificante 19 .…”