Ghrelin and memory: Differential effects on acquisition and retrieval

Carlini, Valeria Paola; Ghersi, Marisa; Schiöth, Helgi B.; Barioglio, Susana Rubiales de

doi:10.1016/j.peptides.2010.02.021

Cited by 65 publications

(47 citation statements)

References 35 publications

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“…GHSR expression in many regions of the brain like hypothalamus], substantia nigra, pars compacta (SNpc) -this implies a role for this hormone in the CNS. It has been shown to increase memory retention in mice 37 It is interesting to point out that in the present study both the basti karmas produced remarkable anti-amnesic effect. It is possible that part of the effect might be due to increased formation of this hormone.…”

Section: Anti-parkinson's Activitysupporting

confidence: 59%

“…It also increased the turnover of dopamine in the dorsal striatum. Based on this it can be suggested that the test basti karma's may be enhancing the formation of ghrelin both in the gut and brain leading to attenuation of parkinsonian like symptoms in the experimental animals 37 .…”

Section: Anti-parkinson's Activitymentioning

confidence: 97%

“…Scopolamine,is a well-known the cholinergic neurotransmission blocker This cholinergic dysfunction is responsible for cognition impairment in rats leading amnesic effect. 37 It has also been reported that memory impairment induced by scopolamine in rats is associated with altered brain oxidative stress status also hence scopolamineinduced memory deficit model is used as animal model for screening anti-dementia drugs. As mentioned earlier in the present study both test basti procedures MB and MTB produced marked reversal of scopolamine induced amnesic effect.…”

Section: Cooks Pole Climbing Jumping Responsementioning

confidence: 99%

“…Furthermore, nearly every chemical that controls the brain in the head has been identified in the gut, including hormones and neurotransmitters. 37 The GI tract hormones are secreted by epithelial cells lining the lumen of stomach and small intestine. The hormones are secreted in to the blood and thus circulate systemically and can influence the functioning at different organs.…”

Section: Anti-parkinson's Activitymentioning

confidence: 99%

“…Further its activation leads to increased neurogenesis this may provide protection against degeneration of neurons seen in Parkinsonian disease. 37 The role of the other hormones in the brain is being elucidated. Thus, it seems that many of the therapeutic benefits of basti karma may be mediated through modulation of ENS and its linkage to brain.…”

Section: Anti-parkinson's Activitymentioning

confidence: 99%

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An Experimental Study to Evaluate the Effect of Basti Karma Over Rats: An Evidence Based Ayurveda Therapy for Parkinsons Disease

Rao¹,

Basavrajeswari²,

Ravishankar³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease. Understanding of Parkinson's disease in terms of Ayurveda can be done under the Vatavyadhi, to be specific, caused due to the Avarana of vata. By keeping all these points Madhu taillika basti was selected for study. To give preclinical support to this study Animal experimentation was carried out on Albino rats to determine the influence of Matra basti (MB) and Madhu tailika basti (MTB) on Psychoneuro-pharmacological activity profile. The present study aimed at assessing the antiParkinsonian activity of the test basti against well-known experimental models. Healthy Wistar albino rats of either sex weighing about 150-200 g were selected and divided into 4 groups. Group 1 Control group, Group 2 Standard group (activity specific), Group 3 Basti group (ordinary or nonMurchita tila taila) and Group 4 Test group (Madhu tailika basti). Animal experimentation revealed that both Matra basti and Madhu tailika basti have produced highly significant anti-depressant effect in behavioural 'despair' test. Both produced significant anti-anxiety activity, open field apparatus test a complex behavior pattern was observed. In the memory and learning related test both the test procedures did not affect the learning process significantly but both produced remarkable reversal of the amnesic effect of scopolamine, this indicates memory enhancing effect. Similarly, antiamnesic effect was observed in CAR based protocol also. Both improved the performance of the rats on the rota rod. Both the test procedures produced good anti-parkinsonian activity. Animal experimentation revealed that both Matra basti and Madhu tailika basti have no effect on general gross behavior.

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Section: Anti-parkinson's Activitysupporting

confidence: 59%

Section: Anti-parkinson's Activitymentioning

confidence: 97%

Section: Cooks Pole Climbing Jumping Responsementioning

confidence: 99%

Section: Anti-parkinson's Activitymentioning

confidence: 99%

Section: Anti-parkinson's Activitymentioning

confidence: 99%

See 3 more Smart Citations

An Experimental Study to Evaluate the Effect of Basti Karma Over Rats: An Evidence Based Ayurveda Therapy for Parkinsons Disease

Rao¹,

Basavrajeswari²,

Ravishankar³

et al. 2017

Int. J. Res. Ayurveda Pharm.

View full text Add to dashboard Cite

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Chronic ghrelin administration restores hippocampal long‐term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease

2018

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Alzheimer's disease (AD), as a common age-related dementia, is a progressive manifestation of cognitive decline following synaptic failure resulted majorly by senile plaques composed of deposits of amyloid beta (Aβ). Ghrelin is a multifunctional peptide hormone with receptors present in various brain tissues including hippocampus and has been associated with neuroprotection, neuromodulation, and memory processing. Here, we investigated the neuroprotective and therapeutic effects of intracerebroventricular (icv) ghrelin infusion for 2 weeks on passive avoidance learning (PAL), memory retention, and synaptic plasticity in the hippocampal dentate gyrus (DG) and CA1 of both normal rats and Aβ1-42-induced neurotoxicity in AD model. Male Wistar rats were evaluated for their passive memory performance using a shuttle box while some groups had already received Aβ1-42 and/or chronic ghrelin. Using field potential recording, the induction of short- and long-term potentiation (STP and LTP) was studied in DG granule cells along with the LTP changes in CA1 pyramidal neurons through stimulation of the medial perforant path (mPP) and Schaffer collaterals (SCs), respectively. Our results demonstrated that chronic ghrelin treatment not only improved memory processing and retrieval in normal rats during the PAL task, but also promoted memory retention and alleviated memory loss by amelioration of Aβ1-42-induced synaptic plasticity impairment in AD subjects through augmentation of field excitatory postsynaptic potential (fEPSP) slope that led to LTP restitution in both the mPP-DG and the CA3-CA1 synapses. Meanwhile, STP was not significantly changed, meaning that although ghrelin enhanced postsynaptic excitability in DG, it did not change presynaptic transmitter release significantly. This suggests the involvement of postsynaptic mechanisms in long-term ghrelin-enhanced memory. In conclusion, it can be inferred that chronic ghrelin administration has an auspicious therapeutic value for impaired cognitive performance and memory deficits in AD-like neuropathology.

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