Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line

Tsubouchi, Hironobu; Onomura, Hitomi; Saito, Yûsuke; Yanagi, Shigehisa; Miura, Ayako; Matsuo, Ayako; Matsumoto, Nobuhiro; Nakazato, Masamitsu

doi:10.1507/endocrj.64.s41

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Breast and colon cancer cell lines express both GHSR1a and GHSR1b (11, 29, 35). However, ghrelin receptors were not notably expressed in lung cancer cell-lines, specifically in non-endocrine subtype (75, 116). Differential expression of ghrelin receptors was even observed among different cell-lines of the same type of cancer.…”

Section: Discussionmentioning

confidence: 92%

Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

et al. 2019

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Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent disagreement in the results of in-vitro and clinical studies that investigated ghrelin association to one type of cancer. These inconsistencies have hampered the indications to consider ghrelin as a potential tumor biomarker or therapeutic agent in cancer patients. Previous studies have reviewed different parts of current literature about the ghrelin-cancer relationship. Although they have highlighted these controversial results in various ways, no specific recommendations have been given to address it. In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to use the following approaches to unravel the inconsistencies detected: (a) to distinguish local and systemic effects of ghrelin in interpreting its summary clinical role in each cancer; (b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines. These approaches could have notable implications for future in-vitro and clinical studies.

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Section: Discussionmentioning

confidence: 92%

Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

et al. 2019

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“…The study found that treatment with ghrelin had no effect on viability or proliferation capacity of the cell and hence concluded that ghrelin had no effect on cancer progression in lung adenocarcinoma cells [151].…”

Section: Effect On Tumor Growthmentioning

confidence: 96%

“…Another study explored results of ghrelin on molecular mechanisms related to cancer advancement, comprising cell viability, proliferation, resistance to apoptosis, and mitochondrial activity using human lung adenocarcinoma cell line HLC-1 [151]. The study found that treatment with ghrelin had no effect on viability or proliferation capacity of the cell and hence concluded that ghrelin had no effect on cancer progression in lung adenocarcinoma cells [151].…”

Section: Effect On Tumor Growthmentioning

confidence: 99%

Ghrelin as a Promising Therapeutic Option for Cancer Cachexia

Khatib

Gaidhane

et al. 2018

Cell Physiol Biochem

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Cachexia is a devastating complication of cancer and an important cause of morbidity and mortality and can have a great effect on quality of life, and sense of self-esteem. Unfortunately; there is no standard cure available for cancer cachexia. Ghrelin; a 28 amino acid orexigenic gut hormone and its mimetics have shown potential benefits in reversing the breakdown of protein and weight loss in catabolic states like cancer cachexia. Ghrelin has effects on several vital pathways in the regulation of appetite, and composition of the body. It increases the secretion of growth hormone and reduces energy expenditure. It plays an important role in regulation of processes associated with cancer and antagonizing protein breakdown in catabolic conditions such as cancer cachexia. Additionally, ghrelin has anti-inflammatory, anti-apoptotic and anxiolytic effects. Administration of ghrelin for short-term has been found to be well-tolerated and safe. These versatile actions of ghrelin and its safety can render it as a potentially useful novel therapy for patients with cancer cachexia. However; there is a need to generate more evidence to support the use of ghrelin in the management of cancer cachexia.

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“…A summary of these findings regarding GI tumor cells and highlighting the diversity of results published on this topic can be found in Table I . Ghrelin has also been reported to be expressed in experimental studies using cell lines of leukemia ( 95 ), breast carcinoma ( 96 ), pulmonary adenocarcinoma ( 97 ), pancreatic ductal adenocarcinoma ( 98 ), prostate carcinoma ( 99 ), gastric adenocarcinoma ( 100 ) and colorectal adenocarcinoma ( 101 , 102 ). and it has shown pleiotropic effects in the vast majority of these tumor cell lines ( 11 ).…”

Section: Experimental Studies and Their Role In Understanding The Ghrelin Axis In Cancer Developmentmentioning

confidence: 99%

Ghrelin and its role in gastrointestinal tract tumors (Review)

et al. 2021

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Ghrelin, an orexigenic hormone, is a peptide that binds to the growth hormone secretagogue receptor; it is secreted mainly by enteroendocrine cells in the oxyntic glands of the stomach. Ghrelin serves a role in both local and systemic physiological processes, and is implicated in various pathologies, including neoplasia, with tissue expression in several types of malignancies in both in vitro and in vivo studies. However, the precise implications of the ghrelin axis in metastasis, invasion and cancer progression regulation has yet to be established. In the case of gastrointestinal (GI) tract malignancies, ghrelin has shown potential to become a prognostic factor or even a therapeutic target, although data in the literature are inconsistent and unsystematic, with reports untailored to a specific histological subtype of cancer or a particular localization. The evaluation of immunohistochemical expression shows a limited outlook owing to the low number of cases analyzed, and in vivo analyses have conflicting data regarding differences in ghrelin serum levels in patients with cancer. The aim of this review was to examine the relationship between ghrelin and GI tract malignancies to demonstrate the inconsistencies in current results and to highlight its clinical significance in the outcome of these patients.

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Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line

Cited by 4 publications

References 14 publications

Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy

Ghrelin as a Promising Therapeutic Option for Cancer Cachexia

Ghrelin and its role in gastrointestinal tract tumors (Review)

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