Ghrelin, leptin and high-molecular-weight adiponectin in relation to depressive symptoms in older adults: Results from the Longitudinal Aging Study Amsterdam

Andĕl, M; Schoor, Natasja M. van; Korten, Nicole; Heijboer, Annemieke C.; Drent, Madeleine L.

doi:10.1016/j.jad.2021.09.069

Cited by 15 publications

(14 citation statements)

References 39 publications

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“…This association got clearer when only examining men. This finding is in line with results from previous studies where the link between leptin and MDD was reproducibly strongest in older men ( 28 , 29 , 31 , 62 ). When interpreting these results, it has to be kept in mind that leptin levels are known to be reduced in elderly women when compared to elderly men ( 63 ).…”

Section: Discussionsupporting

confidence: 93%

“…However, the authors found that higher baseline ghrelin serum levels were associated with higher CES-D scores after 3 years. This effect was only significant in younger and lean participants ( 34 ). Our results are in line with these findings insofar that we too did not find a significant association between depressive symptoms and ghrelin serum levels.…”

Section: Discussionmentioning

confidence: 84%

“…In 2022, van Andel et al published the first study with this premise. They investigated the relationship of ghrelin serum levels and depressive symptomatology as assessed with the CES-D in a cross-sectional manner at two time points 3 years apart ( 34 ). As in our study, no significant associations were found at baseline assessment between ghrelin levels and CES-D scores.…”

Section: Discussionmentioning

confidence: 99%

“…No association of leptin with depressive symptomatology was described in one study ( 30 ). In general, the link between leptin and depressive symptoms seems to be more pronounced in men ( 31 ). Increased adiponectin levels have been described in sub-syndromal depression ( 32 ), but in moderate and severe depression they did not differ from healthy controls ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

“…Whether ghrelin, leptin and adiponectin serum levels increase as a consequence of a disease state, i.e., a depressive episode in MDD or as a consequence of depressive symptomatology which is present during a depressive episode is unclear. Only one very recent study investigated the association between ghrelin and adipokine serum levels and depressive symptomatology thus far ( 34 ). They found no association between total ghrelin, leptin and adiponektin serum levels and depressive symptomatology in a cross-sectional analysis at baseline.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

et al. 2022

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BackgroundGhrelin and the adipokines leptin and adiponectin have been suggested to be involved in mood and anxiety regulation and to be altered in affective disorders. However, studies investigating the association between ghrelin, leptin and adiponectin and depressive symptomatology are scarce but might contribute to a better understanding of their involvement in mood regulation. We thus aimed investigating the association between depressive symptomatology and total ghrelin as well as leptin and adiponectin serum levels in a large population-based sample.MethodsTotal serum ghrelin, adiponectin and leptin levels were determined in 1666 subjects of a population-based cross-sectional study (“LIFE”). The Center for Epidemiological Studies Depression Scale (CES-D) and the Inventory of Depressive Symptoms – Self Rating (IDS-SR) were administered. Multiple linear regression analyses were conducted to examine the association between total serum ghrelin, leptin and adiponectin and the intensity of depressive symptoms.ResultsIn the total sample (n = 1,092), neither ghrelin nor leptin or adiponectin serum levels showed a significant association with CES-D or IDS-SR sum scores (N = 1,092) or in depressed/non-depressed subjects. Leptin serum levels showed a significantly positive association with IDS-SR sum scores in elderly men (≥60 years; β = 0.122, 95% CI: 0.009; 0.236; p = 0.035).ConclusionOur study suggests that peripheral levels of ghrelin and adipokines in a cross-sectional study design might not be sufficient to measure their involvement in depression, suggesting that associations are more complex and multi-layered.

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