Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population

Yoon, Sujung; Pae, Chi Un; Lee, Heejin; Choi, Bo-Moon; Kim, Tae Suk; Lyoo, In Kyoon; Kwon, Do Hoon; Kim, Daijin

doi:10.1016/j.neures.2005.08.013

Cited by 17 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When MA is smoked, the user tends to consume more of it than by other methods. When smoking is compared with intravenous injection, the dose of MA use in this study was 3-60 times higher than that of Yoon et al's paper [60]. They reported an average dose per week in 119 MA users was 0.41 g/week and their mode of intake was intravenous injection (typical in Korean MA users).…”

Section: Relationships Between Ma Dose Frequency and Ma Concentratiocontrasting

confidence: 57%

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Han

Paulus

Wittmann

et al. 2011

Journal of Chromatography B

View full text Add to dashboard Cite

Section: Relationships Between Ma Dose Frequency and Ma Concentratiocontrasting

confidence: 57%

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Han

Paulus

Wittmann

et al. 2011

Journal of Chromatography B

View full text Add to dashboard Cite

“…Inclusion criterion was injecting drug users with the diagnosis of substance dependence that reflected a maladaptive pattern of substance use and significant functional impairment for more than a year. Diagnosis was confirmed by the consensus of two board-certified psychiatrists according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) with the using of a modified version of semi-structured interview [Yoon et al, 2005]. Since recent drug use might influence the response to the self-rating questionnaires, injecting drug users were confirmed to be abstinent from the abused drug for at least 30 days based on the results of weekly drug monitoring.…”

Section: Participantsmentioning

confidence: 99%

Prevalence and associated clinical characteristics of hepatitis B, C, and HIV infections among injecting drug users in Korea

Min

Yoon

Lee

et al. 2013

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

Injecting drug use is associated with an increased risk of blood-borne viral infections, such as hepatitis B and C viruses (HBV and HCV, respectively) and human immunodeficiency virus (HIV). However, their prevalence, virological characteristics, and associated factors are not clear among the injecting drug users in Korea. The aim of this study was to determine the prevalence of HBV, HCV, and HIV infection, as well as their virological and clinical characteristics of injecting drug users in South Korea. Between 2007 and 2010, 318 injecting drug users (89.3% male; mean ± age 41.9 ± 8.15 years) were participated. While HIV infection was not found, the seroprevalence of anti-HCV and HBV surface antigen (HBsAg) was 48.4% (n = 154) and 6.6% (n = 21), respectively. HBV/HCV co-infection was found in 4.1% (n = 13). Occult HBV infection was suggested in 5.0% (n = 16). Among the HCV genotypes, 1b (37.7%) and 2a/2c (35.7%) were mostly often detected. HCV RNA was detected in 98.1% (n = 151/154) and high-level viremia (HCV RNA level, ≥400,000 IU/ml) were observed in 59.6% (n = 90/151). In multiple logistic regression analysis, old age (OR 1.18 per year, 95% CI = 1.09-1.27) and ever-sharing injecting equipment (OR 4.17, 95% CI = 1.39-12.45) independently predicted HCV mono-infection. The prevalence of HBV and HCV infection were high but largely undiagnosed in the present sample of Korean injecting drug users. Strategic prevention, screening, and treatment are needed to reduce further transmission and morbidity.

show abstract

“…With that association ghrelin can affect other various reward behaviors in addition to food intake. Ghrelin augments hyperactivity and arousal due to cocaine, has antidepressant-like properties and is associated with greater alcohol consumption and craving 32,33,54,59,60 . Cocaine is a stimulant agent like methylphenidate but, unlike methylphenidate, it is illegal and has neurotoxic and addictive properties.…”

Section: Discussionmentioning

confidence: 99%

“…In the last few years there has been mounting evidence that ghrelin is related to psychostimulant drug addiction [30][31][32][33] . In addition, ghrelin interacts with CART (Cocaine-and Amphetamine Regulated Transcript) peptides, which are known to be important in psychostimulant addiction / rewarding / reinforcing mechanisms [81][82][83] .…”

Section: Discussionmentioning

confidence: 99%

“…Ghrelin is also involved in more complex cognitive-behavioral processes like learning, memory, reward, addiction and depressive and anxious symptoms 14,29 . In addition, it has been suggested that ghrelin (by a mechanism similar to compensatory increase to food restriction) could be important in drug, stimulant and alcohol abuseaddiction mechanisms [30][31][32][33] . As a result, it is important to design studies to investigate possible interactions between methylphenidate and ghrelin because ADHD increases the risk of drug and alcohol abuse.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of Long Acting Methylphenidate on Ghrelin Levels in Male Children with Attention Deficit Hyperactivity Disorder: An Open Label Trial

Yalcin

İşeri

Bukan

et al. 2014

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

View full text Add to dashboard Cite

ÖZET:Dikkat eksikliği hiperaktivite bozukluğu olan erkek çocuklarında uzun etkili metilfenidatın ghrelin düzeylerine olan etkisi: Açık uçlu bir çalışma Amaç: Dikkat eksikliği hiperaktivite bozukluğu için sıklıkla kullanılan metilfenidatın en sık görülen yan etkileri iştah kaybı, vücut ağırlığında azalma ve başlangıçta olan büyüme geriliğidir. Baskın olarak mideden salınan ghrelin beslenme davranışını arttırır, enerji tüketimini ve lokomotor aktiviteyi azaltır, kilo alımı ve yağ depolanmasını arttırır ve ayrıca gastrointestinal motiliteyi etkiler. Ghrelin metilfenidatın çocuklar üzerindeki metabolik ve anoreksijenik etkileri ile ilişkili olabilir. Bu çalışmanın amacı metilfenidatın ergenlik dönemi öncesi dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda açlık serum aktif ghrelin düzeyleri üzerine olan etkisini araştırmaktır. Ergenlik öncesi erkek çocuklarında ağızdan alınan ozmotik kontrollü salınımı olan 18 mg/gün metilfenidat ile tedavi öncesi ve sonrası ghrelin düzeylerinde değişiklik saptamayı bekledik. Yöntem: Dikkat eksikliği hiperaktivite bozukluğu olan 6-12 yaş arasındaki otuz üç erkek çocuğu çalışmaya alındı. 60 günlük metilfenidat tedavisi öncesi ve sonrasındaki ghrelin düzeyleri dışında, diğer laboratuar bulguları, beden-kitle indeksi, beden-kitle indeksi persentilleri, boy, vücut ağırlığı ve dikkat eksikliği hiperaktivite bozukluğu semptom şiddeti ölçümleri de analize alındı. Bulgular: Metilfenidat tedavisi ile serum aktif ghrelin düzeylerinde bir farklılık saptanmadı. Metilfenidat boy, vücut ağırlığı ve beden kitle indeksi üzerinde önemli bir değişiklik yapmadan ve ciddi bir yan etki oluşturmadan dikkat eksikliği hiperaktivite bozukluğunun dikkat bozukluğu, hiperaktivite, dürtüsellik temel bulgularında iyileşme sağlamıştır. Tartışma: Bu çalışma metilfenidatın serum aktif ghrelin düzeyleri üzerine olan etkisini belirlemeye yönelik ilk çalışmadır. Dikkat eksikliği hiperaktivite bozukluğu ile yakından bağlantılı obezite, alkol ve madde bağımlılığı, ödül sistemi bozukluklarının ghrelinle ilişkisi nedeniyle daha yüksek metilfenidat dozlarıyla ya da atomoksetin ve amfetamin gibi stimulanlarla da ileri araştırmalar yapılmalıdır.Anahtar sözcükler: dikkat eksikliği hiperaktivite bozukluğu, ghrelin, metilfenidat, psikostimülanlar Effects of long acting methylphenidate on ghrelin levels in male children with attention deficit hyperactivity disorder: an open label trial Objective: The most commonly reported side effects of methylphenidate, which is generally used for attention deficit hyperactivity disorder, are loss of appetite, decrease of body weight and initial growth retardation. Ghrelin, which is dominantly released by the stomach, promotes feeding, decreases energy expenditure and locomotor activity, enhances weight gain and fat mass deposition and also effects gastrointestinal motility. Ghrelin may be related to the metabolic and anorexigenic effects of methylphenidate in children. The aim of this study was to investigate methylphenidate's effect on fasting serum active ghrelin levels in prepubert...

show abstract

Ghrelin precursor gene polymorphism and methamphetamine dependence in the Korean population

Cited by 17 publications

References 24 publications

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Hair analysis and self-report of methamphetamine use by methamphetamine dependent individuals

Prevalence and associated clinical characteristics of hepatitis B, C, and HIV infections among injecting drug users in Korea

Effects of Long Acting Methylphenidate on Ghrelin Levels in Male Children with Attention Deficit Hyperactivity Disorder: An Open Label Trial

Contact Info

Product

Resources

About