Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

“…Thyoredoxin system and histidine-containing compounds, such carnosine, homocarnosine, and anserine are very important antioxidants in brain. 41,48 The ability of carnosine to protect tissues against oxidative stress has been previously demonstrated in in vivo experiments under hypoxic and ischemic conditions. 49,50 Involvement of some other mechanisms of antioxidant effect of ghrelin should also be considered.…”

“…39 Kheradmand's studies showed that ghrelin has antioxidant properties in the rat testis and ovary tissues. 40,41 Moreover, one study proposed that ghrelin increases activity of SOD, CAT, GSH-Px in 3T3 L1 preadipocytes. 42 In our study activity of brain GPx, SOD and catalase were not influenced significantly by ghrelin administration.…”

Ghrelin effects on midgut tissue antioxidative defense and glutathioneS-transferase activity in Lymantria dispar (Lepidoptera)

“…Ghrelin has been shown to increase the antioxidative defense system and to inhibit lipid peroxidation in many mammal tissues, including the gastrointestinal tract (Kheradmand et al, 2010). SOD belongs to the first line of defense against free radicals in L. dispar, catalyzing the dismutation of superoxide anion radical (O 2ˉ) into hydrogen peroxide (H 2 O 2 ).…”

Effect of in ovo ghrelin administration on serum malondialdehyde level in newly-hatched chickens

“…After identification of ghrelin in mammals by Kojima et al [2] so many relative studies were conducted on ghrelin properties. Studies conducted during last decade suggested various specifies and functions for ghrelin, such as GH-releasing [3] , osteogenesis [4,5] , hematopoiesis [6,7] , food intake and energy balance and regulation [8,9] , endocrine/ paracrine roles in pancreas [10,11] , and currently antioxidative effects [12,13] . Peptide structure of chicken ghrelin has 26 amino acids with 54% similarity to rat ghrelin [14] .…”

“…Malondialdehyde (MDA) is the organic compound with the formula CH 2 (CHO) 2 and it is a bio-marker of oxidative stress in an organism and an increase of MDA level demonstrates oxidative stress [16] . Anti-oxidative activity of ghrelin has been reported in numerous studies [12,13,17] . Reports of Işeri et al [17] indicated anti-oxidative activity of ghrelin and its ameliorative ability for alendronate-induced oxidative stress, as MDA comes back to the control level after ghrelin infusion.…”