Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients

Hubacek, Jaroslav A.; Bloudíčková, Silvie Rajnochová; Bohuslavová, Romana; Táborský, P; Polakovič, Vladimír; Sazamová, M.; Svítilová, Eva; Vlasák, Jičí; Sojková, Iva; Ryba, M; Knetl, P; Ullrych, Martin; Drahozal, Radim; Pavuková, Veronika; Pavlíková, Beata; Fischlová, D; Mokrejšová, Magdaléna; Chmelíčková, Hana; Pauchová, Eva; Vyskocil, Pavel; Nýdlová, Zuzana; Kopenec, J; Fixa, P; J, Hajný; Bubenícek, P; Syrovatka, Petr; Zahálková, J; Šurel, Stanislav; Hobzek, Zdeněk; Hrubý, Aleš; Suchanová, Jana; Vankova, Svetlana; Brabcová, Jana; Viklický, Ondřej

doi:10.1515/cclm.2007.141

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…We have genotyped 995 (out of 1014 collected, 565 males and 449 females,) adult patients (mean age 66.9 ± 12.7 years, CR 97.8%), who were undergoing haemodialysis for at least three months in 27 haemodialysis units across all over the Czech Republic; the centres were selected primarily on the basis of their willingness to participate in the study (Hubacek et al 2007). The most common verified causes of end stage renal failure was diabetic nephropathy (N = 102), chronic tubulointerstitial nephropathy (N = 99) and nephrosclerosis based on hypertension (N = 39).…”

Section: Methodsmentioning

confidence: 99%

Apolipoprotein E Polymorphism in Hemodialyzed Patients and Healthy Controls

Hubacek

Bloudíčková

Kubínová³

et al. 2009

Biochem Genet

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The possible association between the end-stage renal disease (ESRD) and apolipoprotein E (APOE) polymorphism was found in some, but not all studies. We have analysed the APOE genotypes in 995 haemodialysed patients (cases) and a sample of 6242 healthy individuals (controls) in the Czech Republic. There was a statistically significant difference in the frequencies of APOE alleles between the cases and controls, with more carriers of the APOE2 allele in ESRD patients (15.9%) than in controls (12.2%) (p=0.005). The odds ratio of ESRD for the APOE2 allele, compared with APOE3E3 homozygotes, was 1.37 (95% confidence interval 1.13-1.67). The strength of the association increased with the time spent on haemodialysis: the odds ratios of all-cause ESRD in patients dialysed for 8 or more years, 1-8 years and less than one year (non-survivors) were 1.27 (0.94-1.71), 1.41 (1.09-1.81) and 1.94 (0.88-4.18), respectively. This study suggests that the APOE2 allele is a possible genetic risk factor for all-cause ESRD in Caucasians.

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Section: Methodsmentioning

confidence: 99%

Apolipoprotein E Polymorphism in Hemodialyzed Patients and Healthy Controls

Hubacek

Bloudíčková

Kubínová³

et al. 2009

Biochem Genet

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“…Moreover, TNF-α reduces the concentration of ghrelin, a hunger-stimulating hormone. Administration of ghrelin to healthy volunteers instantly induces hunger [22]. This study showed a slight increase in TNF-α concentration in the C group (Fig.…”

Section: Resultsmentioning

confidence: 58%

Clinical immunology Effect of diet on selected parameters of antioxidative system and inflammatory processes in patients dialyzed due to diabetic kidney disease

Bogacka¹,

Balejko²,

Bober³

et al. 2013

cejoi

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The aim of the study was to determine the effect of balanced diet on selected parameters of oxidative stress, immunological response and nutritional status in patients undergoing haemodialysis (HD) due to diabetic kidney disease. Forty HD patients took part in the study. The nutritional status and diets of all the patients were initially assessed and the patients were divided into two groups. The control group (C) got unchanged diet regarded by those patients as optimal. For patients in the P group, a standard diet for a patient undergoing haemodialysis treatment was introduced, considering the fundamental disease -diabetes. Albumin, total protein, leptin and interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) cytokine concentrations were determined in blood plasma, and CAT and SOD enzymes activity was determined in erythrocytes by

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“…The present study aimed to understand the association between ghrelin and cardiovascular function by measuring the plasma ghrelin levels of the hemodialysis (HD) patients, continuous ambulatory peritoneal dialysis (CAPD) patients and the control group, by analyzing the correlation between ghrelin and the associated indexes and by exploring the correlation between the plasma ghrelin levels and their corresponding echocardiography indicators in these three groups. A previous study indicates that ghrelin is closely associated with malnutrition, inflammation and atherosclerosis ( 4 ). The study of the correlation between ghrelin and malnutrition with dialysis patients has been reported previously ( 5 ), but the correlation between ghrelin and cardiovascular function in patients with dialysis remains to be assessed.…”

Section: Introductionmentioning

confidence: 99%

Plasma ghrelin levels in association with left ventricular function and nutritional status in dialysis patients

Liu

Chi

et al. 2016

Biomedical Reports

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The present study investigated the association between ghrelin levels and the cardiac function and malnutrition of dialysis patients. The aim was to examine the conducive use of exogenous ghrelin to improve the malnutrition, protect the cardiovascular function with dialysis patients in the future. The study included 30 continuous ambulatory peritoneal dialysis (CAPD) patients and 30 hemodialysis (HD) patients undertaking treatment between March 2013 and March 2014. The control group included a total of 30 healthy physical examinees. The plasma ghrelin levels were measured by the enzyme-linked immunosorbent assay to collect the clinical materials and biochemical parameters. The plasma ghrelin levels were 4.28±1.07, 4.63±1.08 and 2.00±0.48 ng/ml in the CAPD, HD and control groups, respectively, and statistical significance was identified between the three groups; F=75.106, P<0.0001. The plasma ghrelin levels in the CAPD group were positively correlated with left ventricular ejection fraction (LVEF) (r=0.506, P=0.004) and were negatively correlated with body mass index (BMI) (r=−0.556, P=0.001). The plasma ghrelin levels in the CAPD and HD groups were positively correlated with serum creatinine (Scr) and blood urea nitrogen (BUN). In conclusion, the plasma ghrelin levels of patients in the CAPD and HD groups were higher compared to those of the control group, which demonstrated that dialysis patients could not effectively remove the plasma ghrelin. The present study found that the plasma ghrelin levels were positively correlated with LVEF, and high levels of ghrelin will exhibit protective effects on the cardiovascular function of CAPD patients. Plasma ghrelin levels were positively correlated with Scr and BUN levels in CAPD and HD patients, and were negatively correlated with BMI in CAPD patients, which showed that ghrelin was correlated with malnutrition of dialysis patients.

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Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients

Abstract: Common ghrelin variants may have an effect on changes in biochemical and anthropometric parameters in hemodialyzed patients over time and could be used in the future to plan individualized therapy.

Cited by 7 publications

References 11 publications

Apolipoprotein E Polymorphism in Hemodialyzed Patients and Healthy Controls

Apolipoprotein E Polymorphism in Hemodialyzed Patients and Healthy Controls

Clinical immunology Effect of diet on selected parameters of antioxidative system and inflammatory processes in patients dialyzed due to diabetic kidney disease

Plasma ghrelin levels in association with left ventricular function and nutritional status in dialysis patients

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