Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant

Bouguila, Jihéne; Mabrouk, Sameh; Tilouche, Samia; Bakir, D.; Trabelsi, Amel; Hmila, Amel; Boughammoura, L.

doi:10.4254/wjh.v5.i4.226

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Secondly, the use of contraception, confirmed by 39% of women participating in the study, may reduce the absorption of vitamins, including vitamins involved in erythropoiesis. Additionally, some authors indicated that viral infections, especially of the Parvoviridae family [21] and autoimmunology diseases [22], also are the factors affecting the occurrence of anaemia. However, these factors could not be taken into account in our study.…”

Section: Discussionmentioning

confidence: 99%

Risk of Anaemia in Population of Healthy Young People Inhabiting a Region in Central Europe

Gutowska¹,

Seidler²,

Mierzwa³

et al. 2013

Journal of Nutrition and Metabolism

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It is quite unbelievable but significant percentage of young healthy women is at risk of anaemia despite proper nutritional state. In this study we decided to determine the lack or excess of which nutrients in a diet can lead to any effects. The major cause of anaemia is not, as in many studies on nutritional status, the deficiency in iron in a diet. Iron intake in women with anaemia exceeded AI (Adequate Intake) level. 120 people took part in the study. Average HGB concentration in female group amounted to 12.45 g/dL and in male group to 14.35 g/dL. Anaemia was determined in 29% women and 4.2% men. In group of women with anaemia a statistically higher intake of SFA, cholesterol, and sucrose and lower intake of pyridoxine, folacin, niacin, and vitamin E, Mn, Cu, Zn, Fe, and Mg were determined. In a group of men with low haemoglobin concentration a statistically higher intake of sucrose but lower intake of fat, especially SFA and MUFA, vitamin C and zinc were observed. Therefore, together with anaemia in the group of women there are coexisting deficiencies in other nutrients, as compared to the group of men. Prevention in both groups should include various supplements.

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Section: Discussionmentioning

confidence: 99%

Risk of Anaemia in Population of Healthy Young People Inhabiting a Region in Central Europe

Gutowska¹,

Seidler²,

Mierzwa³

et al. 2013

Journal of Nutrition and Metabolism

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“…Treating those patients is challenging and early management is crucial to prevent irreversible liver failure [ 24 ]. Relapses often occur and complete remission is difficult to obtain [ 25 , 26 ]. Additionally, those cases have an increased risk of severe to fatal infections [ 24 ].…”

Section: Warm Antibody Aiha (W-aiha)mentioning

confidence: 99%

Autoimmune Hemolytic Anemia in the Pediatric Setting

Voulgaridou

Kalfa

2021

JCM

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Autoimmune hemolytic anemia (AIHA) is a rare disease in children, presenting with variable severity. Most commonly, warm-reactive IgG antibodies bind erythrocytes at 37 °C and induce opsonization and phagocytosis mainly by the splenic macrophages, causing warm AIHA (w-AIHA). Post-infectious cold-reactive antibodies can also lead to hemolysis following the patient’s exposure to cold temperatures, causing cold agglutinin syndrome (CAS) due to IgM autoantibodies, or paroxysmal cold hemoglobinuria (PCH) due to atypical IgG autoantibodies which bind their target RBC antigen and fix complement at 4 °C. Cold-reactive antibodies mainly induce intravascular hemolysis after complement activation. Direct antiglobulin test (DAT) is the gold standard for AIHA diagnosis; however, DAT negative results are seen in up to 11% of warm AIHA, highlighting the need to pursue further evaluation in cases with a phenotype compatible with immune-mediated hemolytic anemia despite negative DAT. Prompt supportive care, initiation of treatment with steroids for w-AIHA, and transfusion if necessary for symptomatic or fast-evolving anemia is crucial for a positive outcome. w-AIHA in children is often secondary to underlying immune dysregulation syndromes and thus, screening for such disorders is recommended at presentation, before initiating treatment with immunosuppressants, to determine prognosis and optimize long-term management potentially with novel targeted medications.

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“…10 As with the present patient, GCH-AIHA has partial response to steroids with a need for high doses of numerous immunosuppressive drugs and lack of persistent response. 4,16 Early initiation of steroids has been shown to have a beneficial effect for both liver function and AIHA. 10,13 Steroids can significantly reduce the mortality in the early active phase.…”

Section: Results Of Laboratory Tests From the Day Of Admission To Tmentioning

confidence: 99%

Giant cell hepatitis and Coomb’s positive autoimmune hemolytic anemia: a case report and literature review

Isa¹,

Ali²,

Mohamed³

et al. 2014

J Bah Med Soc

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Giant cell hepatitis (GCH) with autoimmune hemolytic anemia (AIHA) is a rare disease occurring early in childhood. The exact cause of this illness is unknown and is assumed to be an autoimmune disorder. This disease often has a fatal outcome due to poor response to immunosuppression. In this paper, we report an 11-month-old male infant who presented initially with Coomb's positive autoimmune hemolytic anemia followed by histology-proven GCH and rapid progression to fulminant hepatic failure and death within two months from the onset of the disease despite aggressive immunosuppression. In addition, we review the available literature about the clinical presentation, diagnosis and therapeutic options of this rare disease.

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Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant

Cited by 10 publications

References 7 publications

Risk of Anaemia in Population of Healthy Young People Inhabiting a Region in Central Europe

Risk of Anaemia in Population of Healthy Young People Inhabiting a Region in Central Europe

Autoimmune Hemolytic Anemia in the Pediatric Setting

Giant cell hepatitis and Coomb’s positive autoimmune hemolytic anemia: a case report and literature review

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