Giant Cell Myocarditis Manifested as Fulminant Myocarditis

Abstract

A 42 year-old female with fulminant myocarditis became acutely ill following a distinct viral prodrome 2 weeks before her hospitalization. She had severe ventricular dysfunction and multiple foci of giant cell myocarditis on the histopathological study. She experienced severe hemodynamic compromise that required high-dose vasopressors, immunoglobulin and extracorporeal membrane oxygenation (ECMO). Although she was managed with aggressive pharmacologic and mechanical support and also heart transplantation, she died at hospital day 12.