Giant-cell tumor of the fourth metacarpal bone in children: case report

Abstract

Giant-cell tumor is a rare benign tumor that generally arises in long bones of the lower extremity in adults. The involvement of the metacarpal bone in children is extremely rare. The authors report the case of an 8-year-old boy admitted for a painless swelling of the posterior surface of the fourth right metacarpal bone. The radiological examination showed an expansile osteolytic lesion with a multilocular appearance. Total resection of the metacarpal bone and reconstruction with free fibular graft was performed. We highlight the rarity of this neoplasm in childhood and discuss epidemiological, clinical, radiological, and therapeutical characteristics of this pathology.

Giant Cell Tumor of the Metacarpal: Case Report

“…Treatment of the tumor includes intralesional curettage with adjuvant treatment (polymethyl methacrylate, phenol, burr, +/− bone graft), local versus wide excision and reconstruction, and amputation. 1,2 Wide resection is indicated for cases with extensive bone destruction or articular involvement, as seen in our patient. Recurrence rates following wide excision range from 7% to 15%.…”

A Rare Location of Aneurysmal Bone Cyst in Children: The Patella

“…They can also evaluate the extraosseous extent of the lesion. However, it is well known that neither CT scan nor MRI adds anything to plain radiographs in establishing the diagnosis of aneurysmal bone cyst [15].…”

Multicentric Giant Cell Tumor of the Fourth and Fifth Metacarpals with Lung Metastases

“…They usually occur in young adults (ages 25-40), have a slight female predominance, and are very rare in children [1]. The tumors are usually found in the epiphysis, with or without extension into the metaphysis, of the distal femur, proximal tibia, distal radius, proximal humerus, or sacrum.…”

“…The primary signaling mechanism that controls tumor growth includes receptor activator of nuclear factor kappa B (RANK) and RANK ligand (RANKL) [8,15,18]. Targeted therapy for GCTB consists of monoclonal antibodies to RANKL (denosumab) [1]. The most common chromosomal abnormality is a bonding together of telomeres ("telomeric fusion") from various separate chromosomes [8,15].…”