Giant Condyloma Acuminatum Treated Successfully with Mild Local Hyperthermia: Two Case Reports

Wei, Zhen-Dong; Sun, Yuzhe; Qi, Ruiqun; Jin, Mingzhu; Gao, Xing‐Hua

doi:10.2340/00015555-3759

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…Studies have depicted that hyperthermia at 42-45 • C can promote migrational maturation of Langerhans cells, improve their antigen-presenting ability, and clear HPV-infected keratinocytes by establishing a specific cellular immune response (9). In addition to treating plantar warts, local hyperthermia has also been reported to have achieved surprising results in treating giant condyloma acuminatum, immunodeficient patients with extensive warts, and extensive flat warts (10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Clinical observation and study of local hyperthermia for treating plantar warts: A pilot study with 38 patients

Chen

Xu²,

Li³

et al. 2023

Front. Med.

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Warts are benign lesions caused by infection of the keratinocytes by the human papillomavirus (HPV). There is still no consensus on the standard treatment for plantar warts, and the various treatments (both destructive and non-destructive) have variable efficacy with a long list of shortcomings, such as higher recurrence, pain, and scarring. Local hyperthermia was considered a safe, effective, and promising therapy in the treatment of plantar warts. After getting approval from the hospital’s ethics committee, the present study was designed to assess the clinical efficacy of local hyperthermia in the treatment of plantar warts. A total of 38 patients were enrolled in the study, and all patients received a standard regimen in a 5-week schedule, with local 45°C treatment for 30 mins on days 1, 2, 3, 14, 15, 22, 29, and 36. Of the 38 patients, complete resolution of the warts was observed in 13 (34.2%), 8 (21.1%) achieved partial remission, and 17 (44.7%) revealed poor response to the treatment. Patients were followed up for at least 3 months, and there was no recurrence of lesions in the 13 clinically cured patients at the last follow-up. The findings in the current study demonstrate that local hyperthermia is a safe, effective, and promising therapy for the treatment of plantar warts.

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Section: Discussionmentioning

confidence: 99%

Clinical observation and study of local hyperthermia for treating plantar warts: A pilot study with 38 patients

Chen

Xu²,

Li³

et al. 2023

Front. Med.

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“…Most patients present symptoms between the 4th and 6th decade of life [3]. Risk factors for BLT include: smoking, alcoholism, local chronic inflammation, immune deficiency (individuals diagnosed with HIV, transplant and diabetic patients), multiple sexual partners, poor hygiene [3,5,10,11]. The overall mortality is 20% [6,8].…”

Section: Discussionmentioning

confidence: 99%

“…In some cases the patients can benefit from immunotherapy with imiquimod [3,6,8,11]. In addition, Wei, Zhen-Dong et al reported that Mild Local Hyperthermia can successfully induce remission of GCA lesions [10].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of perineal area developed from the Buschke–Löwenstein tumor

2023

Folia Medica Cracoviensia

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“…Local hyperthermia has been applied for the treatment of viral skin infections, including plantar warts, flat warts, condyloma acuminatum and molluscum contagiosum. [11][12][13][14] Additionally, the use of hyperthermia in cases of cutaneous Mycobacterium marinum and subcutaneous granuloma annulare has also been reported. 15,16 Hyperthermia can be used to selectively eliminate cancer cells via facilitation of cell cycle arrest, apoptosis, necrosis and autophagy, especially in epithelial tumour cell lines.…”

Section: Introductionmentioning

confidence: 99%

“…Local hyperthermia has been applied for the treatment of viral skin infections, including plantar warts, flat warts, condyloma acuminatum and molluscum contagiosum 11–14 . Additionally, the use of hyperthermia in cases of cutaneous Mycobacterium marinum and subcutaneous granuloma annulare has also been reported 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia is a promising potential adjunct to treating sporotrichosis: A refractory case of HIV sporotrichosis and in vitro experiments on Sporothrix spp.

Liu,

Song,

Guan

et al. 2023

Mycoses

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BackgroundHyperthermia is a common monotherapy for sporotrichosis, but only in patients with special conditions, such as pregnancy and nursing. However, hyperthermia has not been used more widely for sporotrichosis in clinical practice.Patients/MethodsAn HIV‐positive adult male with lymphocutaneous sporotrichosis caused by Sporothrix globosa that did not respond to conventional itraconazole therapy lasting > 2 months received adjunctive therapy with local hyperthermia. To simulate the effects of heat exposure on growth and morphology of Sporothrix spp. in vitro, S. globosa, S. schenckii, and S. brasiliensis were exposed to intermittent heat (42°C) for 1 hour a day for 7 or 28 days and observed under transmission electron microscopy.ResultsItraconazole combined with local hyperthermia significantly improved the lesions, and the patient was successfully cured of sporotrichosis, with no recurrence after 2 years of follow‐up. Cultures of Sporothrix spp. treated with 7 days of daily heat exposure in vitro showed obvious decreases in colony diameters, but not numbers, compared with untreated cultures (p < 0.001). After 28 days of heat exposure in vitro, Sporothrix spp. were unable to thrive (p < 0.001), and ultrastructural alterations, including loose cell wall structure, incomplete cell membrane, disrupted vacuoles, and fragmented nuclei, were noticeable.ConclusionsOur case findings and in vitro experiments on Sporothrix spp., together with a literature review of previous sporotrichosis cases, suggest that hyperthermia has a clinical role as a treatment adjunct. Large‐scale clinical trials are required to examine the utility of hyperthermia in various forms of cutaneous sporotrichosis.

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Giant Condyloma Acuminatum Treated Successfully with Mild Local Hyperthermia: Two Case Reports

Cited by 4 publications

References 10 publications

Clinical observation and study of local hyperthermia for treating plantar warts: A pilot study with 38 patients

Clinical observation and study of local hyperthermia for treating plantar warts: A pilot study with 38 patients

Squamous Cell Carcinoma of perineal area developed from the Buschke–Löwenstein tumor

Hyperthermia is a promising potential adjunct to treating sporotrichosis: A refractory case of HIV sporotrichosis and in vitro experiments on Sporothrix spp.

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