Giant dermatofibroma

Requena, Luis; Fariña, M C; Fuente, C; Piqué, Enric; Olivares, M.; Martin, L; Yus, Evaristo Sánchez

doi:10.1016/s0190-9622(08)81500-9

Cited by 52 publications

(12 citation statements)

References 11 publications

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“…2,10 Negative immunohistochemistry for CD34, S100 and epithelial markers helps to rule out dermatofibrosarcoma protruberans, schwannoma and naevi or renal cell carcinoma, respectively. 3 This case is the second reported occurrence of GCDF 12 and the 27th of combined DF. Furthermore, it was the largest size plaque surrounded by numerous giant DFs (satellitosis) 3 which had a hitherto unreported combination of deep penetrating, sclerotic collagen with admixed epithelioid cells, myxoid degeneration, xanthoma cells and myofibroblasts.…”

Section: Reportmentioning

confidence: 68%

“…1,2 DF has diverse clinical variants, including giant (> 5 cm in diameter), 3 atrophic, 1,2 atypical polypoid 1,2 and DF with satellitosis. It commonly involves the extremities, usually the lower legs.…”

Section: Reportmentioning

confidence: 99%

“…3,8 Diagnosis is difficult because of the large size of the lesion and the atypical histopathology. 3,8 Diagnosis is difficult because of the large size of the lesion and the atypical histopathology.…”

Section: Reportmentioning

confidence: 99%

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Giant combined dermatofibroma with satellitosis

Sehgal¹,

Sardana

Khandpur

et al. 2004

Clin Exp Dermatol

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An unusual giant combined dermatofibroma is reported in a 34-year-old man who presented with skin-coloured swellings on the medial aspect of the left scapula. The plaque was well defined, reddish-brown and 25-30 cm in diameter. It was also tender and indurated. Several similar smaller lesions (satellites) were present around the plaque. Light microscopy of an incisional biopsy from the main lesion showed architectural features of a deep penetrating type of dermatofibroma, with xanthomatous aggregates, myxoid changes and probable myofibroblastic differentiation. Our case represents an extraordinary example of giant combined dermatofibroma with satellitosis. Despite its benign nature, a wide excision is contemplated because of its unsightly appearance and physical discomfort.

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Section: Reportmentioning

confidence: 68%

Section: Reportmentioning

confidence: 99%

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Giant combined dermatofibroma with satellitosis

Sehgal¹,

Sardana

Khandpur

et al. 2004

Clin Exp Dermatol

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“…There is a female preponderance amongst the patients with dermatofibroma 1 . Dermatofibroma is round or ovoid, firm, dermal nodules and they are usually ＜1 cm in diameter 2 . The diagnosis is usually straightforward if the classical clinical and pathologic features are evident.…”

Section: Introductionmentioning

confidence: 99%

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

et al. 2011

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Background: Many variants of dermatofibromas have been described, and being aware of the variants of dermatofibromas is important to avoid misdiagnosis. Objective: We wanted to evaluate the clinical and pathologic characteristics of 122 cases of dermatofibromas. Methods: We retrospectively reviewed the medical records and 122 biopsy specimens of 92 patients who were diagnosed with dermatofibroma in the Department of Dermatology at Eulji Hospital of Eulji University between January 2000 and March 2010. Results: Nearly 80% of the cases occurred between the ages of 20 and 49 years, with an overall predominance of females. Over 70% of the lesions were found on the extremities. The most common histologic variant was a fibrocollagenous dermatofibroma (40.1%). Other variants included histiocytic (13.1%), cellular (11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic (6.5%), monster (4.9%), palisading (1.6%) and keloidal dermatofibromas (0.8%). There were 9 dermatofibromas (7.3%) that were the mixed type with two co-dominant histologic features. Conclusion: The results of this study are consistent with previous reports on the clinical features of dermatofibromas. However, we observed several characteristic subtypes of dermatofibroma and we compared the frequency of the histologic subtypes.

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“…The giant variant of DF was first described by Danckaert and Karassik, 7 and is defined on the basis of its large size (> 5 cm) and pedunculated appearance. This lesion shows conventional histology and benign biological clinical behavior 8 . More recently a new type of DF has been described: the plaque‐like variant, 9 predominantly occurring in males, and showing large size, absence of pedunculation and frequent association with multiple satellites lesions 9 …”

mentioning

confidence: 99%