Giant glomangioma

Naversen, Douglas N.; Worland, Ronald G.; Burket, John M.

doi:10.1016/s0190-9622(86)80184-0

Cited by 5 publications

(4 citation statements)

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“…Naversen et al [8]observed a 12-year-old girl who had developed, since the age of 2 years, multiple glomus tumors involving the right arm in a 30 × 10 cm area (fig. 1b).…”

Section: Review Of Case Reportsmentioning

confidence: 99%

Type 2 Segmental Manifestation of Multiple Glomus Tumors: A Review and Reclassification of 5 Case Reports

Happle

König²

1999

Dermatology

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Background: In various autosomal dominant skin disorders, segmental forms reflecting mosaicism have been reported. Recently, two different types of mosaic manifestation have been delineated. Type 1 reflects heterozygosity for the underlying mutation and shows a degree of severity as observed in the corresponding nonmosaic phenotype. Type 2 originates from loss of heterozygosity, shows an excessively severe involvement and is usually superimposed on the disseminated lesions of the ordinary trait. Objective: We wanted to exemplify further the proposed rule of dichotomy. Methods: We have screened the literature on multiple glomus tumors, a trait that follows an autosomal dominant mode of transmission. Results: We found 5 cases of multiple glomus tumors suggesting a type 2 segmental involvement. In all of these cases, a unilateral band-like or patchy arrangement of excessively pronounced glomus tumors was associated with disseminated lesions corresponding to the ordinary phenotype, and in 3 cases other family members were affected with disseminated glomus tumors. The unilateral agminated lesions were reported to be present in early childhood, whereas the disseminated lesions appeared later. Conclusion: Multiple glomus tumors can be added to the list of autosomal dominant skin disorders that may show a type 2 segmental involvement.

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“…Naversen et al [8]observed a 12-year-old girl who had developed, since the age of 2 years, multiple glomus tumors involving the right arm in a 30 × 10 cm area (fig. 1b).…”

Section: Review Of Case Reportsmentioning

confidence: 99%

Type 2 Segmental Manifestation of Multiple Glomus Tumors: A Review and Reclassification of 5 Case Reports

Happle

König²

1999

Dermatology

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“…A benign glomus tumor occurs as either a solitary mass or multiple lesions (Table 1) [1,2,5,6,12,[16][17][18]. The solitary tumor is the more common.…”

Section: Discussionmentioning

confidence: 99%

“…It is often subungual; however, it can also be extradigital. Multiple glomus tumors are referred to as a glomangioma or a glomuvenous malformation (Table 1) [1,2,5,6,12,[16][17][18]. A glomangioma occurs less frequently than a solitary glomus tumor and can be inherited in an autosomal dominant manner.…”

Section: Discussionmentioning

confidence: 99%

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Glomus Extradigital Tumor: A Case Report of an Extradigital Glomus Tumor on the Wrist and Comprehensive Review of Glomus Tumors

Cohen¹

2023

Cureus

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A glomus tumor is a neoplasm composed of cells from the glomus body which is a contractile neuromyoarterial structure that affects blood pressure and thermoregulation by altering cutaneous blood flow. This cutaneous tumor can be benign or rarely malignant, solitary or multiple, and digital or extradigital. A benign glomus tumor usually presents as a non-familial, solitary, and subungual lesion. Multiple glomus tumors are less common, may be autosomal dominantly inherited, and extradigital. In contrast to a digital glomus tumor that often occurs within the nailbed or fingertip pulp of a young woman, a glomus extradigital tumor (GET) typically appears on the extremity or trunk of an older man. The diagnosis of a glomus tumor may be suspected based on clinical evaluation; it classically presents with a clinical triad of symptoms which includes lesion-associated tenderness, pin-point pressure pain, and cold sensitivity. However, cold-induced exacerbation of pain is frequently absent in extradigital glomus tumors; this may contribute to a delay in establishing the diagnosis of a glomus tumor in these individuals. Radiographic studies can support the diagnosis, but tissue specimen examination is necessary to establish the diagnosis. Resolution of tumor-associated pain is usually achieved following the complete excision of the neoplasm. A woman with a glomus tumor located on her wrist is described; her painful tumor was not sensitive to cold and was misdiagnosed clinically as a possible foreign body reaction to either a wood splinter or glass shard. The diagnosis of an extradigital glomus tumor was established after a microscopic examination of the tissue specimen following an excisional biopsy using a 3-millimeter punch biopsy tool. The neoplasm-related pain ceased and did not recur after the tumor had been completely removed. In conclusion, a glomus tumor is included in the differential diagnosis of a painful cutaneous neoplasm; however, misdiagnosis and/or substantial delay in diagnosis may occur if the tumor is extradigital or it lacks cold sensitivity or both. Therefore, the clinician needs to entertain the possibility of an extradigital glomus tumor when evaluating a patient with a tender, temperature-insensitive skin lesion that is not located on the fingers or toes.

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