Giant magnetoimpedance-based microchannel system for quick and parallel genotyping of human papilloma virus type 16/18

Abstract

Quick and parallel genotyping of human papilloma virus (HPV) type 16/18 is carried out by a specially designed giant magnetoimpedance (GMI) based microchannel system. Micropatterned soft magnetic ribbon exhibiting large GMI ratio serves as the biosensor element. HPV genotyping can be determined by the changes in GMI ratio in corresponding detection region after hybridization. The result shows that this system has great potential in future clinical diagnostics and can be easily extended to other biomedical applications based on molecular recognition.

Microfluidic microsystem for magnetic sensing of nanoparticles with Giant Magneto-Impedance technology

“…Giant Magneto-Impedance (GMI) materials are promising since their sensitivity and noise properties are better than those of GMR sensors [4]. GMI microribbons or microwire have been used for static detection of magnetic nanoparticules [5]. The novelty of this work is to explore the use of GMI microwires for the detection of magnetic nanoparticules flowing in a microfluidic channel.…”

Nanomaterial-Based Biosensor as an Emerging Tool for Biomedical Applications

“…Yang et al, 131 reported a giant magnetoimpedance (GMI)-based microchannel system for genotyping of human papilloma virus (HPV) 16/18. HPV infection is an important carcinogenic factor in the uterine cervix.…”

“…83,131 The GMR biosensor is based on the detection of the magnetic fringe FIGURE 1. Schematic illustration of a nanobiosensor consisting of biomolecules, linker layer, nanomaterials, electrode, and substrate.…”

Tuning giant magnetoimpedance response of Fe75.5Si13.5B7Nb3Cu1 amorphous ribbon by laser ablation

“…Recently, the development of high-performance magnetic sensors has benefited from the discovery of the new magnetic phenomenon. Magnetic sensors based on GMI can be applied in engineering and industrial sectors, biomagnetic detection, geomagnetism, etc., where high resolution magnetic field and localized small magnetic fields were detected [1][2][3][4]. Experimentally, many soft magnetic materials have exhibited excellent GMI effect, such as Co-based, Fe-based amorphous wires and ribbons, FeNi films and other soft magnetic composite structures [5][6][7][8][9].…”