Giant magnetoresistive biosensor for myoglobin immunoassay

Yang, Hua; Qu, Bingjun; Lei, Bo; Xie, Li

doi:10.1109/icsens.2011.6126981

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…In recent years, rapid biological detection based on GMR and MTJ sensors and biochips is a hot issue. This is due to its interesting features such as being fast, cheap, user-friendly and acceptable high sensitivity [9][10][11][12][13][14]. As there is less magnetic material in body fluid, the magnetic signal detected by GMR and MTJ biosensors suffers minimally from the interferences of body fluid and therefore, exhibits a high sensitivity.…”

Section: Gmr and Mtj Microarray Biochipsmentioning

confidence: 99%

“…Recent studies focus on the high sensitivity and multi-target microarray biochips for accurate and early disease diagnosis. They also discuss treatment that is based on silicon compatible technologies due to its low cost, large-scale and readily integration with signal extraction and processing front-end and back-end circuits monolithically for a lab-on-a-chip solution [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Such studies oppose conventional assays that are currently used in hospitals and laboratories, e.g., enzyme-linked immunosorbent assay (ELISA) [17] and fluorescent detections [18], etc.…”

Section: Introductionmentioning

confidence: 99%

“…Although there are many different forms of microarray biochips, they can be generally classified into two categories, based on the sensing methodologies: labelled and label-free. Labelled techniques tag an analyte of interest with an externally observable label such as a magnetic tag [9][10][11][12][13][14][15][16] or fluorophore [18]. On the other hand, label-free techniques detect an intrinsic property of the biomolecule such as the electrochemical charge/current [3][4][5][6][7][8], mass, thermal reactivity, etc.…”

Section: Introductionmentioning

confidence: 99%

“…For example, CMOS, due to its low cost, large-scale and readily integration with signal extraction and processing front-end and back-end circuits monolithically for a lab-on-a-chip solution. State-of-the-art silicon-based IMB assays include the electrochemical microarray biochip [3][4][5][6][7][8], GMR and MTJ microarray biochips [9][10][11][12][13][14] and the fully CMOS compatible oscillator microarray biochip [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Silicon-based Integrated Microarray Biochips for Biosensing and Biodetection Applications

Zhang¹,

Zhu²,

Geng³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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The silicon-based integrated microarray biochip (IMB) is an inter-disciplinary research direction of microelectronics and biological science. It has caught the attention of both industry and academia, in applications such as deoxyribonucleic acid (DNA) and immunological detection, medical inspection and point-of-care (PoC) diagnosis, as well as food safety and environmental surveillance. Future biodetection strategies demand biochips with high sensitivity, miniaturization, integration, parallel, multi-target and even intelligence capabilities. In this chapter, a comprehensive investigation of current research on state-of-the-art siliconbased integrated microarray biochips is presented. These include the electrochemical biochip, magnetic tunnelling junction (MTJ) based biochip, giant magnetoresistance (GMR) biochip and integrated oscillator-based biochip. The principles, methodologies and challenges of the aforementioned biochips will also be discussed and compared from all aspects, e.g., sensitivity, fabrication complexity and cost, compatibility with silicon-based complementary metal-oxidesemiconductor (CMOS) technology, multi-target detection capabilities, signal processing and system integrations, etc. In this way, we discuss future siliconbased fully integrated biochips, which could be used for portable medical detection and low cost PoC diagnosis applications.

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Section: Gmr and Mtj Microarray Biochipsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Silicon-based Integrated Microarray Biochips for Biosensing and Biodetection Applications

Zhang¹,

Zhu²,

Geng³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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Ultrasensitive protein detection: a case for microfluidic magnetic bead-based assays

2013

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We review the use of magnetic micro- and nanoparticles ('magnetic beads') in microfluidic systems for ultrasensitive protein detection. During recent years magnetic beads have been used frequently in immunoassays, either as mobile substrates on which the target antigen is captured, as detection labels, or simultaneously as substrates and labels. The major part of the reviewed work has as application the detection of antibodies or disease biomarkers in serum or of biotoxins from food samples. Several of the most sensitive assays allow protein detection down to fg mL(-1) concentrations. We benchmark the performance of these microfluidic magnetic bead-based assays with the most promising earlier work and with alternative solutions.

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