Giant papillary conjunctivitis: A review

Kenny, Sarah E.; Tye, Cooper B.; Johnson, Daniel A.; Kheirkhah, Ahmad

doi:10.1016/j.jtos.2020.03.007

Cited by 31 publications

(39 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…33,34 Proteins that change their conformational state following sorption to contact lenses can potentially initiate inflammatory responses possibly leading to local or general papillary responses. 35 However, the absolute quantities of native and inactive lysozyme remaining on the senofilcon A lens material with the use of either lens care product is two orders of magnitude less than that found on an FDA group IV lens, etafilcon A, following use of an MPS care product. 3,30 There was no significant difference in the percentage of inactive lysozyme determined when using either solution.…”

Section: Discussionmentioning

confidence: 99%

Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Heynen¹,

Ng²,

Martell³

et al. 2021

OPTH

View full text Add to dashboard Cite

The amount of protein deposition on soft contact lenses and to what extent the proteins are denatured may have an impact on comfortable wearing times of contact lenses. The purpose of this study was to evaluate the effects of two lens care systems on total protein and the quantity and activity of lysozyme deposited on worn senofilcon A, silicone hydrogel contact lenses. Participants and Methods: Thirty symptomatic soft contact lens wearers were enrolled into a 4-week prospective, randomized, bilateral eye, daily-wear, crossover, double-masked study. Participants were fitted with biweekly senofilcon A lenses and were assigned either a polyquaternium-1 and myristamidopropyl dimethylamine-containing system (OPTI-FREE RepleniSH) or a peroxide-based system (CLEAR CARE). After each wear period, proteins were extracted from the lenses and analyzed for total protein, total lysozyme quantity and activity. Results: The use of either the peroxide-based system or the polyquaternium-1 and myristamidopropyl dimethylamine-containing system resulted in no difference (P>0.05) to the amount of total protein deposited on the lenses (6.7 ± 2.8 micrograms/lens versus 7.3 ± 2.8 micrograms/lens, respectively) or to the amount of denatured lysozyme deposits (0.8 ± 0.7 versus 0.9 ± 0.7 micrograms/lens), respectively. The total amount of lysozyme deposited on the lenses was significantly lower when using the peroxide-based system (1.3 ± 0.9 micrograms/lens) compared to the polyquaternium-1 and myristamidopropyl dimethylaminecontaining system (1.7 ± 1.0 micrograms/lens) (P=0.02). Conclusion:The inactivation of lysozyme deposited on senofilcon A lenses when disinfected with the peroxide-based or the polyquaternium-1 and myristamidopropyl dimethylamine-containing systems were neither statistically nor clinically significant and the overall amounts of denatured lysozyme recovered from the lenses were low (<1 microgram/lens).

show abstract

Section: Discussionmentioning

confidence: 99%

Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Heynen¹,

Ng²,

Martell³

et al. 2021

OPTH

View full text Add to dashboard Cite

show abstract

“…Morgan et al ( 23 ) observed a small increase in papillary conjunctivitis grades in 30 SiH CL wearers in the first month of the 1-year follow-up, with no changes in limbal redness. Papillary conjunctivitis is an inflammatory condition that can be mechanically or immunologically mediated ( 33 ). In CL wearers, the etiology appears to be principally mechanical and may be related to changes in surface wetness ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes of Ocular Surface in First-Time Contact Lens Wearers and the Effective Factors of Contact Lens Discomfort

Shu

et al. 2022

Front. Med.

View full text Add to dashboard Cite

PurposeThe purpose of the study is to investigate the dynamic changes in ocular surface indicators in first-time contact lens (CL) wearers and identify the most influential factors in CL discomfort (CLD).MethodsA total of 26 healthy non-CL wearers (26 eyes) were recruited and fitted monthly with disposable hydrogel CLs. Each participant underwent a full ocular surface evaluation, which include Efron grading, tear film breakup time, Schirmer's I test, corneal dendritic cell (DCs) imaging by in vivo confocal microscopy (IVCM), and conjunctival microvasculature evaluation by functional slit-lamp biomicroscopy. CLD was assessed using the Ocular Surface Disease Index questionnaire at baseline, 1 week, 1, 3, and 6 months after wearing it and another 6 months after discontinuing it.ResultsClinical signs and CLD were significantly increased in the first week (p < 0.05). The microvascular response and DC activation peaked at the 1-month interval (p < 0.05). During CL wear, CLD is positively correlated with corneal staining (B = 0.238, p = 0.002), papillary conjunctivitis (B = 0.245, p < 0.001), and microvascular blood flow velocity (B = 0.353, p < 0.001). After discontinuation, only DC activation remained elevated at 6 months, whereas the other signs recovered.ConclusionsThe first week of CL wear was the main period for the appearance of ocular surface clinical signs, and the first month was the main period for the activation of subclinical inflammation. Corneal staining and conjunctival microvascular response are the main factors affecting CLD. Even if the clinical signs recover after discontinuing wear, subclinical inflammation may persist.

show abstract

“…The proliferative lesions such as giant papillae are observed in VKC, and in some cases of AKC [2,[7][8][9][10]. In addition, giant papillary conjunctivitis (GPC) may develop as a result of mechanical irritation such as contact lenses [2,7,11].…”

Section: Introductionmentioning

confidence: 99%

Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice

et al. 2021

View full text Add to dashboard Cite

Giant papillary conjunctivitis: A review

Cited by 31 publications

References 89 publications

Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Dynamic Changes of Ocular Surface in First-Time Contact Lens Wearers and the Effective Factors of Contact Lens Discomfort

Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice

Contact Info

Product

Resources

About