Giant pubertal prolactinoma: Complete resolution following short term carbegoline treatment

Oğuz, Ayten; Tüzün, Dilek; Şahin, Murat; Gül, Kamile

doi:10.4103/1119-3077.188693

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Cabergoline shrinks tumor cells and performs best with weekly dosing. It has been shown to be effective even in pituitary adenomas with no function (27) and has been used for years even in giant macroadenomas (28,29). In a study of 26 prolactinomas, bromocriptine was initiated in all cases, and conversion to quinagolide or cabergoline was made due to development of intolerance or resistance to bromocryptine (13).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

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Objective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6%, macroadenomas in 27%, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4%. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n=206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n=27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/mL, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3% were treated with cabergoline and 13.4% with bromocriptine. 20.1% of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised.

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Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren

Ergür

Isguven

et al. 2019

Jcrpe

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“…This agent, which shrinks tumor cells and performs best with weekly use. It has been shown to be effective even in pituitary adenomas with no function (27); and it has been used for years even in giant macroadenomas (28,29).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Eren¹,

Ergür²,

Isguven³

et al. 2018

Jcrpe

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What is already known on this topic?Hyperprolactinemia affects gonadal function in the adolescent. Cabergoline is a useful treatment model for pituitary adenomas.Pituitary surgery for macroadenomas may need in some patients. Some drugs increase the prolactin level. Macroprolactinemia is one of the causes of hyperprolactinemia. What this study adds?Cabergoline is an effective treatment in the adolescent. There is no difference in term of age between the micro-and macroadenomas. Physicians should review surgical indications for macroadenomas. Macroprolactinemia is a neglected cause of hyperprolactinemia in cases with unexplained etiology.

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Giant pubertal prolactinoma: Complete resolution following short term carbegoline treatment

Cited by 2 publications

References 13 publications

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

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